BACKGROUND The aim of the present retrospective study was to analyze clinical outcome and risk factors associated with treatment outcomes according to KRAS status in patient with metastatic colorectal cancer (mCRC) treated with bevacizumab (bev) plus chemotherapy in the first-line setting. METHODS We performed observational study on 1622 patients with mCRC treated with bev plus oxaliplatin- o...

BackgroundThe primary aim of this study was to evaluate the activity intraperitoneal bevacizumab (IP-bev) in delaying re-accumulation malignant ascites women with chemotherapy-resistant epithelial ovarian cancer (CR-EOC) who have ceased chemotherapy. Secondary outcomes were safety and quality life.MethodsWomen CR-EOC that reaccumulated within 28 days their last paracentesis (P-1) administered I...

Vol. I, p. 1971; B. Cowsik and J. McClelland, Phys. Bev. Lett. 29, 669 (1972); Ap. J. 180, 7 (1973)l, or heavier than about 2 GeV (see Ref. 7) and lighter than the temperature of the universe after the gravitinos decay. The last proviso is added here to guarantee that the gauge fermions have time to annihilate; Eq. (4) shows that it can be satisfied only if ~E & 10 ( QeV. This proviso can be so...

Abstract Current standard-of-care for glioblastoma (GBM) includes surgery followed by radiation with concurrent and adjuvant temozolomide. There are limited treatment options available upon progression or recurrence of disease. Options often involve participation in clinical trials promising new therapies. However, patients may not meet the strictly defined entry criteria to participate these t...

A two-dimensional along-the-channel CFD (computational fluid dynamic) model, coupled with a twophase flow model of liquid water and gas transport for a PEM (proton exchange membrane) fuel cell is described. The model considers non-isothermal operation and thus the non-uniform temperature distribution in the cell structure. Water phase-transfer between the vapour, liquid water and dissolved phas...

Picornavirus Type 1 IRESs comprise five principal domains (dII-dVI). Whereas dV binds eIF4G, a conserved AUG in dVI was suggested to stimulate attachment of 43S ribosomal preinitiation complexes, which then scan to the initiation codon. Initiation on Type 1 IRESs also requires IRES trans-acting factors (ITAFs), and several candidates have been proposed. Here, we report the in vitro reconstituti...

In this study, a virus strain designated as HY12 was isolated from cattle with a disease of high morbidity and mortality in Jilin province. Biological and physiochemical properties showed that HY12 isolates is cytopathic with an extremely high infectivity. HY12 is resistant to treatment of organic solvent and acid, and unstable at 60°C for 1 h. Electron microscopy observation revealed the virus...

Smart Distribution Logistik, a german research project, wants to extend the usage of battery electric vehicle (BEV) in inner-city logitics. This goes hand in hand with the desire of german population and politics for less CO2 emmision and noise of the traffic. BEV’s have a number of disadvantages like higher acquisition cost than vehicles with combustion engine, limited driving ranges and high ...