OBJECTIVE To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG). METHODS Participants 55 years and older from the population-based Rotterdam Study underwent, at baseline and at follow-up, the same ophthalmic examination, including visual field screening and stereo optic disc photography. A diagnosis of...

Motivated by recent attempts to quantum simulate lattice models with continuous Abelian symmetries using discrete approximations, we define an extended-O(2) model adding a $\gamma \cos(q\varphi)$ term the ordinary O(2) angular values restricted $2\pi$ interval. In \rightarrow \infty$ limit, becomes extended $q$-state clock that reduces when $q$ is integer and otherwise continuation of for nonin...

glutathione s-transferases (gsts) are members of multigenic family which have the essential functionin cells as an antioxidant. in the present study we studied the polymorphism of gstt1 and gstm1 deletion genotypes in iranian patients with primary closed angle glaucoma (pcag) compared to healthy subjects. we conducted a study of 41 pcag patients (24 women, 17 men) and 100 healthy participants (...

PURPOSE To estimate the relative importance of genes and environment in peripapillary atrophy type beta (beta-PPA) in a classic twin study. METHODS Female twin pairs (n = 506) aged 49 to 79 years were recruited from the St. Thomas' UK Adult Twin Registry. Peripapillary atrophy was identified from masked grading of stereoscopic optic disc photographs. Structural equation modeling was performed...

We present simulation results for the luminosity reduction due to position and angle offsets in the beams colliding at the NLC interaction point. We look at the nominal NLC-B-500 and NLC-B-1000 designs and also at designs having the vertical beta function doubled at the IP. E ects of position and angle o sets on NLC luminosity K.A. Thompson and T.O.Raubenheimer The purpose of this note is to st...

βBlockers lower intraocular pressure (IOP) by reducing the rate of aqueous inflow. Shortly after the commercial release of topical timolol maleate in 1978 it became the most widely used ocular hypotensive agent. Its potency, combined with its twice daily frequency of instillation and lack of induction of miosis or accommodative spasm, was seen as a major advantage. Timolol was considered a revo...

The conformation and membrane topology of the disulfide-stabilized antimicrobial peptide tachyplesin I (TP) in lipid bilayers are determined by solid-state NMR spectroscopy. The backbone (phi and psi) torsion angles of Val(6) are found to be -133 degrees and 142 degrees , respectively, and the Val(6) CO-Phe(8) H(N) distance is 4.6 A. These constrain the middle of the N-terminal strand to a rela...

Neuroligins are post-synaptic cell adhesion molecules that promote synaptic maturation and stabilization upon binding with pre-synaptic partners, the alpha- and beta-neurexins. Using a combination of analytical ultracentrifugation, small angle X-ray, and neutron scattering, we have characterized the low-resolution three-dimensional structure of the extracellular domain of the neuroligins, free ...