Mechanical ventilation has been the mainstay of treatment for respiratory failure. Modern-day mechanical ventilation has evolved from the days of the polio epidemic (1). As intensivists we have appreciated its benefits and risks through many years of experience and research. In striving to “do no harm,” we have adopted methods to ventilate patients that subject them to less lung injury as we tr...

PEA attenuates chemotherapy-induced neuropathies by attenuating endoneueral edema in myelinated nerve fibers [2]. Similarly, PEA improves distal motor latency in individuals with carpal tunnel syndrome [3]. Similar benefits have been noticed in pudendal neuralgias [4]. PEA also exerts beneficial effects in patients with multiple sclerosis by ameliorating neuropathic pain [5]. PEA also increases...

OBJECTIVE To demonstrate, quantify, and mechanistically dissect antiatherosclerotic effects of fenofibrate besides lowering plasma cholesterol per se. METHODS AND RESULTS ApoE*3Leiden transgenic mice received either a high-cholesterol diet (HC) or HC containing fenofibrate (HC+FF) resulting in 52% plasma cholesterol-lowering. In a separate low-cholesterol diet (LC) control group, plasma chole...

Osterix (Osx or Sp7) is a zinc-finger-family transcriptional factor essential for osteoblast differentiation in mammals. The Osx-Cre mouse line (also known as Osx1-GFP::Cre) expresses GFP::Cre fusion protein from a BAC transgene containing the Osx regulatory sequence. The mouse strain was initially characterized during embryogenesis, and found to target mainly osteoblast-lineage cells. Because ...