A series of new benzothiazole derivatives 6a-h have been synthesized, in five steps, from substituted phenols via the 1,3,4-oxadiazole-2-thiones 5a-h. The in vitro antitumor activity of the compounds obtained was investigated and the benzothiazol derivatives 6d and 6e showed strong effects on leukaemia cell lines CCRF-CEM (CC50=12+/-2 micromol L(-1), 8+/-1 micromol L(-1), respectively). These c...

Electrochemical oxidation of the catechols 1a and 1b is studied in the presence of 6-methyl-2-thouracil (3b) and 6-propyl-2-thiouracil (3a) as nucleophiles in a phosphate buffer (0.15 mol L−1, pH = 6.8)/DMF (95:5) solution using cyclic voltammetry and controlled-potential coulometry. The results obtained indicate that the quinones derived from the catechols participate in 1,4-Michael-addition r...

Benzothiazoles are bicyclic ring system with multiple developed and examined, in vitro, their antitumor activity in applications. In the 1950s, a number of 2-aminobenzothiazoles ovarian, breast, lung, renal and colon carnicoma human cell were intensively studied as central muscle relaxants. Since lines. Pyrimido benzothiazole and benzothiazolo then medicinal chemists have not taken active inter...

Abstract. The oxidation of dimethyl sulfide (DMS; CH3SCH3), emitted from the surface ocean, contributes to formation Aitken mode particles and their growth cloud condensation nuclei (CCN) sizes in remote marine environments. It is not clear whether other less commonly measured marine-derived, sulfur-containing gases share similar dynamics DMS contribute secondary aerosol formation. Here, we pre...

In this study an improved process for the production of 5-Methyl-1,2,4-triazolo(3,4-b) benzothiazole fungicide (IV) is described. Firstly, (2-methylphenyl) thiourea (I), 2-amino- 4-methylbenzothiazole (II) and 2-hydrazino-4-methylbenzothiazole (III) as intermediates consequently were prepared. Then IV is synthesized by the reaction of III with formic acid in the presence of p-toluenesulfonic ac...

     In this study an easy, green, efficient and simple approach is reported for the synthesis of some benzothiazole-, benzimidazole- and benzoxazole-2-thiolderivatives. The proposed approach employs the reaction of corresponding aromatic amine with potassium isopropyl xanthate (Z11) in the presence of copper sulfate (CuSO4) as a catalyst under conventional heating and ultrasonic irr...

Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, bi...

QS is a well-known mechanism of bacteria cell-to-cell communication. By inhibiting the quorum sensing pathway, compounds can prevent aggressive activity bacteria, including virulence production, biofilm formation, and other pathogenesis. Herein, authors reported synthesis biological evaluation several benzothiazole-2-thiols toward activities. As result, five are successfully synthesised using m...

A new benzothiazole-based chemosensor BTN (1-((Z)-(((E)-3-methylbenzo[d]thiazol-2(3H)-ylidene)hydrazono)methyl)naphthalen-2-ol) was synthesized for the detection of Cu2+. could detect Cu2+ with “off-on” fluorescent response from colorless to yellow irrespective presence other cations. Limit determined be 3.3 μM. Binding ratio and turned out a 1:1 analysis Job plot ESI-MS. Sensing feature by exp...

In the present study, five new derivatives (GG4 to GG8) of benzothiazoles were synthesized and evaluated against Staphylococcus aureus (MTCC 737), Pseudomonas aeruginosa (MTCC 424), Escherichia coli (MTCC 1687), and yeast-like fungi Candida tropicalis. p-Toluidine on treatment with ammonium thiocynate formed 2-benzothiazolamines (II), which on reaction with hydrazine hydrate formed a hydrazino ...