Antioxidants inhibit the rat liver microsomal mixed-function-oxidase-catalysed hydroxylation of benzo[a]pyrene. These antioxidants also decrease the formation of mutagenic products from benzo[a]pyrene as judged by the Ames bacterial-mutagenicity assay [B.N. Ames, J. McCann & E. Yamazaki (1975) Mutat. Res. 31, 347-364]. It is suggested that antioxidants exert their protective effect against canc...

Pollution of the environment by polycyclic aromatic hydrocarbons (PAHs) is great concern because their persistence, toxicity, mutagenic and carcinogenic nature. The distribution 8 PAHs in water surface sediment from M’Badon Bay (Ebrie Lagoon, Côte d’Ivoire) was investigated using high performance liquid chromatography (HPLC). results showed that mean PAH concentrations ranged 0.08 to 2.70 µg/L ...

REPORTS Dust Concentration in the Atmosphere of the Equatorial North Atlantic: Possible Relationship to the Sahelian Drought: J. M. Prospero and R. T. Nees . Benzo[a]pyrene Diol Epoxides: Mechanism of Enzymatic Formation and Optically Active Intermediates: S. K. Yang et al. Phyllotaxis inXanthium Shoots Altered by Gibberellic Acid: R. Maksymowych and R. 0. Erickson n...............................

Optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrenes [(+)- and (-)-BP 7,8-dihydrodiol] were tested for carcinogenicity by giving newborn mice i.p. injections of 20, 40, and 80 nmol of compound on Days 1, 8, and 15 of life. The animals were killed at 17 weeks of age. Control mice had 0.10 pulmonary adenoma per mouse, whereas animals treated with (+)-BP 7,8-dihydrodiol and (...

Benzo(a)pyrene (B(a)P) is a polycyclic aromatic hydrocarbon with carcinogenic and toxic effects. Doxorubicin is a DNA-interacting drug widely used in chemotherapy. In the present study we investigated the effects of doxorubicin on rats that received benzo(a)pyrene. Sprague-Dawley male rats, 3-4 months old, were divided into 5 groups (n=9 per group). Group 1 (controls) received normal saline int...

Human skin fibroblasts isolated in vitro from subjects carrying the Mediterranean variant of glucose-6-phosphate dehydrogenase exhibit an 85% decrease of this enzymatic activity. There is a 26% and a 94% decrease of the hexose monophosphate shunt and of the reduced nicotinamide adenine dinucleotide phosphate/nicotinamide adenine dinucleotide phosphate ratio, respectively. Incubation with 0.1 mM...

The mutagenic activity of the polycyclic aromatic hydrocar bon-containing fraction of several soot samples was measured in Salmonella typhimurium, using resistance to the purine analog 8-azaguanine as a genetic marker. A postmitochondrial supernatant derived from livers of phénobarbitaland/or Aroclor-pretreated male Sprague-Dawley rats was incorporated into all assays to allow metabolism of pr...

Benzo[a]pyrene is one of a group of chemicals called polycyclic aromatic hydrocarbon, PAHs for short, and found in cigarette smoke, in the exhaust from automobiles and coal tar. Polycyclic aromatic hydrocarbons (PAHs) are toxic environmental pollutants that are known or suspected carcinogens or mutagens. Bioremediation has been used as a general way to eliminate them from the contaminated sites...

The abilities of various mono and dimethyl derivatives of benzo(a)pyrene (BP) to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. 11-Methylbenzo(a)pyrene was found to be approximately 3 times more active as a tumor initiator than was the parent hydrocarbon; 1-methyl benzo(a)pyrene was about twice as active as was BP. Substitution of a methyl group in po...