BACKGROUND Nowadays, removal of heavy metals from the environment is an important problem due to their toxicity. OBJECTIVES In this study, a modified method was used to synthesize chitosan-coated magnetite nanoparticles (CCMN) to be used as a low cost and nontoxic adsorbent. CCMN was then employed to remove Hg(2+) from water solutions. MATERIALS AND METHODS To remove the highest percentage ...

The aim of this study was to investigate the combined influence of 3 independent variables in the preparation of paclitaxel containing pH-sensitive liposomes. A 3 factor, 3 levels Box-Behnken design was used to derive a second order polynomial equation and construct contour plots to predict responses. The independent variables selected were molar ratio phosphatidylcholine:diolylphosphatidyletha...

The current study was aimed to investigate the potential of solid self-nanoemulsifying drug delivery system (SSNEDDS) composed of Capmul MCM C8 (oil), Cremophor RH40 (surfactant) and transcutol P (co-surfactant) in improving the dissolution and oral bioavailability of Nateglinide (NTG). Liquid self-nanoemulsifying drug delivery systems (L-SNEDDS) were developed by using rational blends of compo...

Extraction of lactic acid by emulsion liquid membrane technology (ELM) using n-trioctyl amine (TOA) in n-heptane as carrier within the organic membrane along with sodium carbonate as acceptor phase was optimized by using response surface methodology (RSM). A three level Box-Behnken design was employed for experimental design, analysis of the results and to depict the combined effect of five ind...

Coagulation treatment of sago wastewater was studied and laboratory studies were carried out using alum as coagulant. Coagulation treatment conditions were optimised through response surface methodology (RSM). Operational parameters namely dosage of alum (Al [email protected]

OBJECTIVES A Box-Behnken design was used for evaluation of Eudragit coated diclofenac pellets. The purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design. MATERIALS AND METHODS Diclofenac was loaded onto the non-pareil beads using conventional coating pan. Film coating of pellets was done at the same pan. The effect of plast...

The main purpose of this study is to compare the performance of a group of second-order designs such as Box-Behnken, face-center cube, three-level factorial, central composite, minimum bias, and minimum variance plus bias for estimating a quadratic metamodel. A time-shared computer system is used to demonstrate the ability of the designs in providing good fit of the metamodel to the simulation ...