The blood-brain barrier (BBB) is formed by continuous, closely connected endothelial cells, enveloped in the basal lamina, pericytes, and foot extensions of astrocytes. BBB has a vital role brain metabolism protects parenchyma from harmful agents present systemic circulation. Damage to an increase its permeability have important many neurodegenerative diseases. This paper aims review literature...

Vascular brain diseases are one of the leading causes death and disability in developed countries. Along with acute disturbance cerebral circulation, chronic cerebrovascular diseases, which manifest as vascular cognitive impairment (VCI), great medical social importance. VCIs include a wide range impairments (CI) ranging from subjective CI to mixed dementia. The article discusses pathogenetic c...

Background: Obesity is regarded as the epidemic of diseases correlated with an unhealthy lifestyle. The avoidance of inactivity could prevent obesity and its relevant issues. The present study aimed to explore the effectiveness of the theory of planned behavior (TPB) to improve obesity-preventive lifestyle among Iranian students. Materials and Methods: The current study was a quasi-experimenta...

Abstract Background: Socio-behavioral consulting centers offer methadone maintenance therapy which is a very useful method for drug dependents. These centers offer a wide range of services like education, consulting, prevention, care taking of patients and treatment for high risk groups such as AIDS-infected patients. Methadone maintenance therapy (MMT) is helpful in harm minimization...

Abstract Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to severe forms amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation is also observed in other diseases, with unknown consequences. Here, we show that drives behavioral abnormalities knock-in mice, including locomotor hyperactivity and alterations social interactions, absence widespread neur...

Introduction: Studies suggest that ATP-sensitive potassium (KATP) channels are a potential pharmacotherapeutic target for neuroprotection in neurodegenerative diseases. The current study aimed at evaluating the effect of pretreatment with glibenclamide (Glib) and B vitamins supplement on the severity of behavioral symptoms in 6-hydroxydopamine (OHDA)-induced Parkinsonism. Also malondialdehyde (...

The methodological rationale contains a description of epidemiological research methods, provides an analysis the key concepts epidemiology (population, sample, risk factor (RF)), in context prevention priorities, as well describes each main RFs for noncommunicable diseases (NCDs), including cardiovascular diseases. Emphasis is placed on behavioral and mediated biological RFs, such smoking alco...

Objective Describe the prevalence of chronic diseases in Family Medicine, and to assess the usefulness of these studies at this level of care. Methodology A cross-sectional study, from a secondary analysis of an existing dataset, was carried out in a Family Medicine office in Toledo, Spain. For each patient were collected the variables age, gender and chronic illness according WHO-ICD-10 groups...

this is a mortality study in internal medicine wards of amir-alam hospital, since the beginning of 1374 to end of 1376. here, we reviewed, prevalence of disease lead to death, the ward and invasive interventions and duration of admission of patients before death. in this study, records of 85 patients were reviewed. 68.2% of patients were men and 31.8% women. mean of age was 61.6% with minimum o...