Probiotics are live microorganisms that, when administered in sufficient doses, provide health benefits on the host. The United States Food and Drug Administration (FDA) requires phase I safety studies for probiotics when the intended use of the product is as a drug. The purpose of the study was to determine the safety of Bifidobacterium animalis subsp lactis (B. lactis) strain BB-12 (BB-12)-su...

Retained intraocular BBs are difficult to remove. According to manufacturers' specifications, BBs have a spherical diameter of 4.5 mm and a copper plate covering a steel core. They have only moderate magnetic properties because of the copper plate cover and they are too large to be grasped by almost all intraocular forceps and, therefore, present a problem when they are retained in the eye afte...

PURPOSE Graves' ophthalmopathy (GO) is characterized by the infiltration of immune cells into the orbit, a process in which cytokines play a central role. Orbital fibroblasts are potent producers of cytokines on different stimuli. Recently, the authors showed increased expression of the PDGF-B chain in GO orbital tissue. The dimeric PDGF-BB molecule has been described to activate the NF-kappaB ...

Ulcerative colitis (UC) is a chronic relapsing disease without satisfactory treatments, in which intestinal inflammation and disrupted intestinal epithelial barrier are two main pathogeneses triggering UC. Berberrubine (BB) is deemed as one of the major active metabolite of berberine (BBR), a naturally-occurring isoquinoline alkaloid with appreciable anti-UC effect. This study aimed to comparat...

Background: Recent scientific data demonstrated a potential beneficial effect of beta-blocker (BB) therapy in cardiac patients with chronic obstructive pulmonary disease (COPD). Our aim was to characterize the use of beta-blockers in these patients, in “real-life” conditions. Material and methods: We collected retrospectively the data of 60 consecutive cardiac patients (51 men, 9 women, mean ag...

BACKGROUND/AIMS The most appropriate treatment for acute gastric variceal bleeding (GVB) is currently endoscopic gastric variceal obturation (GVO) using Histoacryl®. However, the secondary prophylactic efficacy of beta-blocker (BB) after GVO for the first acute episode of GVB has not yet been established. The secondary prophylactic efficacy of BB after GVO for the first acute episode of GVB was...

INTRODUCTION Increasing emphasis is being placed on insulin use among patients with type 2 diabetes mellitus (T2DM). Basal-bolus (BB) therapy is regarded as the gold standard, but a high frequency of injections and the general complexity of this therapy are seen as barriers in real-world practice. Here we describe the characteristics and treatment patterns of patients with T2DM receiving BB in ...

We set constraints on the trilinear Higgs boson self-coupling, ?3, by combining information coming from W mass and leptonic effective Weinberg angle, electroweak precision observables, with single analyses targeting ??,ZZ?,WW?,?+?? b¯b decay channels double in bb¯bb¯,bb¯?+?? bb¯?? channels, performed ATLAS collaboration. With assumption that new physics affects only potential, values outside in...

Abstract Background Heart failure with reduced ejection fraction (HFrEF) is the global public health burden a prevalence of 1% adults. The current guidelines suggest use angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), beta-blockers (BB), mineralocorticoid antagonists (MRA), receptor-neprilysin (ARNIs), and sodium-glucose cotransporter-2 (SGLT2i) to reduce m...