Not Mediated by Phosphodiesterase 5 Inhibition To the Editor: A major conclusion of the recent publication of Mullershausen et al1 is that “the physiological effects of BAY 41-2272 . . . are due to the synergism of sensitization of NO-sensitive GC [guanylate cyclase] and inhibition of PDE5.” This conclusion is based on the authors’ finding that BAY 41-2272 stimulates sGC and inhibits human PDE5...

Not Mediated by Phosphodiesterase 5 Inhibition To the Editor: A major conclusion of the recent publication of Mullershausen et al1 is that “the physiological effects of BAY 41-2272 . . . are due to the synergism of sensitization of NO-sensitive GC [guanylate cyclase] and inhibition of PDE5.” This conclusion is based on the authors’ finding that BAY 41-2272 stimulates sGC and inhibits human PDE5...

This paper uses a PSOPC model based non-destructive damage identification procedure using frequency and modal data. The objective function formulation for the minimization problem is based on the frequency changes. The method is demonstrated by using a cantilever beam, four-bay plane truss and two-bay two-story plane frame with different scenarios. In this study, the modal data are provided nume...

desalination plants are potentially capable of having impacts on coastal marine environments due to the production of wastewater with high concentrations of salts (brine discharge) and some heavy metals. the aim of this study was to examine the concentration of accumulated metals (ni, cu, cd, fe, zn, pb) in the sediments near the brine discharge point in the chabahar bay. twenty one sediment sa...

the catch composition of the bottom trawl fishery along the coasts of karataş was evaluated in the 2002-2003 fishing season. a total of 110 species were registered, the fishes showed the highest diversity (90 species) followed by 15 crustaceans species and 5 species of cephalopods. the highest catch per unit effort (cpue) value (66.8 kg h -1 ) was recorded in september when the fishing season w...

this study was undertaken to determine the concentration of mercury in edible muscle of five commercially valuable marine organisms from mosa bay, persian gulf, iran. the total mercury concentrations were determined by cold vapour atomic absorption spectrophotometry and expressed in μg/g dry weight. certified reference materials were used for each batch of analysis. mercury concentration was 0....

Nitric oxide (NO) is the principal mediator of penile erection, and soluble guanylate cyclase (sGC) is the receptor for NO. In pathophysiological conditions when sGC is inactivated and not responsive to NO or sGC stimulators a new class of agents called sGC activators increase the activity of NO-insensitive sGC and produce erection. The aim of this study was to investigate erectile responses to...

The natural eutrophication of lakes is still an accepted concept in limnology, arising as it does from the earliest efforts to classify lakes and place them in an evolutionary sequence. Recent studies of newly formed lakes at Glacier Bay, Alaska, only partially support this idea, and suggest more variable trends in lake trophic development which are under local (catchment-level) control. Here w...

Mitogen-activated protein kinase (MAPK) is activated in the majority of melanomas, and its activity is essential for cell survival. In this report, we examined the effects of a novel raf inhibitor BAY 43-9006 on melanoma cell viability and intracellular signaling and found that it induces apoptosis through a caspase-independent mechanism. At concentrations that suppress extracellular signal-reg...