The goal of this study was to compare responses to a calcium promoter, BAY y 5959, and dobutamine (Dob) in heart failure (HF). Dogs ( n = 9) were chronically instrumented and studied in the conscious state before and after pacing-induced HF. In the control state, BAY y 5959 (20 μg ⋅ kg-1 ⋅ min-1) increased the first derivative of left ventricular (LV) pressure (dP/d t) by 83 ± 8% and mean arter...

Nasu K, Nishida M, Ueda T, Yuge A, Takai N, Narahara H. Application of the nuclear factorB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Am J Physiol Endocrinol Metab 293: E16–E23, 2007. First published August 8, 2006; doi:10.1152/ajpendo.00135.2006.—Most of the current medical treatments for endometriosis aim to downregulate estrogen activity. However, a high rec...

[1] During spring and summer time, coastal upwelling influences circulation and ecosystem dynamics of the Monterey Bay, California, which is recognized as a National Marine Sanctuary. Observations of physical, bio‐optical properties (including bioluminescence) together with results from dynamical biochemical and bioluminescence models are used to interpret the development of the upwelling event...

Guanabara Bay is the second largest bay in the coast of Brazil, with an area of 384 km(2). In its surroundings live circa 16 million inhabitants, out of which 6 million live in Rio de Janeiro city, one of the largest cities of the country, and the host of the 2016 Olympic Games. Anthropogenic interference in Guanabara Bay area started early in the XVI century, but environmental impacts escalate...

The aim of this study was to establish the involvement of acetylcholine (Ach) and calcium ions in modulating contractions induced by Bay K8644 (an agonist of calcium channels located in the cell membrane) and KCl (at depolarizing concentrations), and also to examine the importance of the vascular endothelium in the activity of Bay K8644. The study was performed on perfused Wistar rat tail arter...

Because of the complexity derived from the existence of various phosphoinositide 3-kinase (PI3K) isoforms and their differential roles in cancers, development of PI3K inhibitors with differential pharmacologic and pharmacokinetic profiles would allow best exploration in different indications, combinations, and dosing regimens. Here, we report BAY 80-6946, a highly selective and potent pan-class...

We carried out a study of the spatial and temporal effects of land-derived material on water column nutrients and plankton dynamics in a subtropical estuary. The study had 2 parts: (1) a 3 yr synoptic monitoring program, and (2) a shorter 1.5 yr study during the second half of the program, which focused on individual pulses driven by discrete rainfall events. Although we found spatial differenc...

BAY y 5959 is a dihydropyridine derivative that binds to L-type calcium channels in a voltage-dependent manner and promotes calcium entry into the cell during the plateau of the action potential by influencing mean open time. Because myofilament responsiveness to calcium is preserved in congestive heart failure (CHF), the inotropic responsiveness to this compound should be preserved in CHF, and...

We aimed to characterize the relaxation induced by the soluble guanylyl cyclase (sGC) stimulator 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) and its pharmacological interactions with nitric oxide (NO) in the corpus cavernosum (CC) from wild-type (WT), endothelial nitric-oxide synthase (eNOS)(-/-), and neuronal (n)NOS(-/-) mice. The effec...

Name Ronda R. Henning Margaret Knepper Kevin L. Fox Address Harris Corporation Government Communications Systems Division P.O. Box 37 Mail Stop W2/9703 Palm Bay, FL 32905 Harris Corporation Government Communications Systems Division P.O. Box 37 Mail Stop 2/9450 Palm Bay, FL 32905 Harris Corporation Government Communications Systems Division P.O. Box 37 Mail Stop 2/9450 Palm Bay, FL 32905 Phone ...