Individuals with schizophrenia demonstrate stable deficits in affect recognition. Similar deficits in affect recognition have been observed in those who are at clinical high risk (CHR) of developing psychosis. The current project aimed to longitudinally examine affect processing in CHR individuals, to determine if affect processing predicted later conversion to psychosis and if affect processin...

BACKGROUND Magnesium supplementation has previously shown reductions in blood pressure of up to 12 mmHg. A positive relationship between magnesium supplementation and performance gains in resistance exercise has also been seen. However, no previous studies have investigated loading strategies to optimise response. The aim of this study was to assess the effect of oral magnesium supplementation ...

BACKGROUND The default mode network (DMN) is a set of brain regions typically activated at rest and suppressed during extrinsic cognition. Schizophrenia has been associated with deficient DMN suppression, though the extent to which DMN dysfunction predates psychosis onset is unclear. This study examined DMN suppression during working memory (WM) performance in youth at clinical high-risk (CHR) ...

Our research is based on Constraint Handling Rules (CHR), a powerful language for writing constraint solvers. We investigate connuence of CHR programs. This property guarantees that a CHR program will always compute the same result for a given set of constraints independent of which rules are applied. We give a decidable, suucient and necessary syntactic condition for connuence. Finally we pres...

Our research is based on Constraint Handling Rules (CHR), a powerful language for writing constraint solvers. We investigate connuence of CHR programs. This property guarantees that a CHR program will always compute the same result for a given set of constraints independent of which rules are applied. We give a decidable, suucient and necessary syntactic condition for connuence. Finally we pres...

Fourteen adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) were studied to evaluate the role of imatinib prior to allogeneic stem cell transplantation (SCT). Of these, 12 patients were in complete hematologic response (CHR), and 2 were refractory. Imatinib was administered as an interim schedule after each chemotherapy course. After the first imatinib cycle, 11...

The MuvB complex recruits transcription factors to activate or repress genes with cell cycle-dependent expression patterns. MuvB contains the DNA-binding protein LIN54, which directs the complex to promoter cell cycle genes homology region (CHR) elements. Here we characterize the DNA-binding properties of LIN54 and describe the structural basis for recognition of a CHR sequence. We biochemicall...

Constraint Handling Rules is a logical concurrent committedchoice rule-based language. Recently it was shown that the classical union-find algorithm can be implemented in CHR with optimal time complexity. Here we investigate if a parallel implementation of this algorithm is also possible in CHR. The problem is hard for several reasons: Up to now, no parallel computation model for CHR was define...