Behçet's disease (BD) involves multisystem vasculitis of unknown origin. Ocular manifestations of BD mostly include bilateral panuveitis and retinal vasculitis, which are very challenging to treat. Interferon alfa-2a (IFN) has been recently introduced for treating refractory Behçet uveitis, mainly in Germany and Turkey. Nonetheless, there is so far no consensus about the ideal treatment regimen...

BACKGROUND Behçet's disease (BD) significantly increases morbidity and mortality. BD mainly affects young adults with a peculiar geographical distribution. It has been suggested that BD varies in its phenotypic expression in different ethnic groups. METHODS We investigated potential ethnicity-related differences relative to phenotype and prognosis of BD patients in a French multiethnic countr...

[1] This paper presents a multicontinuum approach to model fractal temporal scaling of catchment response in hydrological systems. The temporal scaling of discharge is quantified in frequency domain by the transfer function HðxÞ, which is defined as the ratio between the spectra of catchment response and recharge time series. The transfer function may scale with frequency x as HðxÞ x2b. While t...

large Vessel Vasculitis Non-specific Aortoarteritis (Takayasu’s arteritis) Aortoarteritis has been well described and studied from India.6Two monograms written by Indian authors are available on the subject.10,11 In contrast to Japanese patients in whom proximal aorta involvement is common ( %), in Indian patients descending and especially abdominal aorta involvement (reversed coarctation) is c...

OBJECTIVE [corrected] To determine the clinical characteristics of patients with myelodysplastic syndrome (MDS)-associated Behçet's disease (BD) in Japan. METHODS 54 Japanese cases of MDS-associated BD obtained from the literature and from our own clinical experience were reviewed. The clinical features of MDS-associated BD were compared with those of the 1991 nationwide BD survey in Japan. ...

Results Case 1 A pediatric case with splenomegaly, cervical lymphoadenopathy, failure to thrive and anemia, was found to have two pathogenic MVK variants, p.V250I and p. L315G*51, and the Q705K variant on the NLRP3 gene, considered a functional polymorphism. Typical symptoms and a high level of urinal mevalonic acid allowed closure on MKD diagnosis this case. Case 2 A pediatric case with recurr...

A 28-year-old woman with no prior pathologic antecedent was admitted to the internal medicine department for a 2month history of intermittent fever and swollen lower limbs. Physical examination showed bilateral pitting leg edema with no inflammatory skin changes. Her body temperature was above 38°C. Vascular echo-Doppler revealed a bilateral primitive iliac vein thrombosis extending to the vena...

A meta-analysis showed that methodological differences in prevalence studies such as a sample survey design or census design may be responsible for some of the variance in BS prevalence reported across countries, in addition to a true geographic variation. Efforts towards developing a data driven core set of outcome measures for clinical trials is continuing. Multimodal imaging using color fund...

to assess the association between polymorphisms of the il-6 -174 g/c and behçet's disease (bd) in tunisian patients. dna was extracted from blood samples taken from 43 tunisian patients and 43 healthy controls. the polymorphisms were analyzed by pcr with the pcr-rflp. no significant association was found between patients and controls concerning polymorphism of il6 -174 g/c between the (allelic ...

Background: Behcet’s disease (Silk Road disease), a rare immune-mediated multisystem inflammatory disorder described by intermittent oralaphthae and genital ulcer, backsliding uveitis, mucocutaneous, articular, gastrointestinal, neurological vascular manifestations, with no cure.It is brought about changes in the: a) arteries that flexibly blood to the body tissues b) veins return lungs, rear o...