Controversy over the frequency of human B1 cells in normal individuals has arisen as different labs have begun to employ non-uniform techniques to study this population. The phenotypic profile and relative paucity of circulating human B1 cells place constraints on methodology to identify and isolate this population. Multiple steps must be optimized to insure accurate enumeration and optimal pur...

Neurons of the cerebral cortex are organized in layers and columns. Unlike laminar patterning, the mechanisms underlying columnar organization remain largely unexplored. Here, we show that ephrin-B1 plays a key role in this process through the control of nonradial steps of migration of pyramidal neurons. In vivo gain of function of ephrin-B1 resulted in a reduction of tangential motility of pyr...

PURPOSE To quantify B1+ variation across the breasts and to evaluate the accuracy of precontrast T1 estimation with and without B1+ variation in breast MRI patients at 3 Tesla (T). MATERIALS AND METHODS B1+ and variable flip angle (VFA) T1 mapping were included in our dynamic contrast-enhanced (DCE) breast imaging protocol to study a total of 25 patients on a 3.0T GE MR 750 system. We compute...

g-Radiation is a potent inducer of apoptosis. There are multiple pathways regulating DNA damage-induced apoptosis, and we set out to identify novel mechanisms regulating g-radiation–induced apoptosis in hematopoietic cells. In this report, we present data implicating the cyclin B1 protein as a regulator of apoptotic fate following DNA damage. Cyclin B1 is the regulatory subunit of the cdc2 seri...

EphB2 is a receptor tyrosine kinase of the Eph family and ephrin-B1 is one of its transmembrane ligands. In the embryo, EphB2 and ephrin-B1 participate in neuronal axon guidance, neural crest cell migration, the formation of blood vessels, and the development of facial structures and the inner ear. Interestingly, EphB2 and ephrin-B1 can both signal through their cytoplasmic domains and become t...

Introduction: At high magnetic field strengths (≥3T) the RF wavelength becomes smaller than the sample size, making transmit magnetic field (B1) inhomogeneity more prominent. RF-shimming [1] and Transmit SENSE [2] have been proposed as methods to minimize this inhomogeneity. To take advantage of these methods it is important to accurately map the B1 field. Saturation prepared with 2 RApid Gradi...

Temperature-sensitive (ts) mutants of vaccinia virus defective in the B1 kinase demonstrate a conditionally lethal defect in DNA synthesis. B1 is the prototypic member of a new family of protein kinases (vaccinia virus-related kinases, or VRK) that possess distinctive B1-like sequence features within their catalytic motifs (R. J. Nichols and P. Traktman, J. Biol. Chem., in press). Given the str...

Five experimental groups were used to evaluate the efficiency of sodium bentonite (BNT) and ascorbic acid (AA) in reducing the toxicity of aflatoxin B1 in ElSalam chicks (Egyptian local chicks) diets. A total number of 450 unsexed one-day old chicks were wing banded, weighted and randomly assigned to 5 groups of five replicates (18 chicks/replicate). The experimental groups were as follow: 1) b...

A 3-year comprehensive analysis of aflatoxin contamination in peanut butter was conducted in Zambia, sub-Saharan Africa. The study analyzed 954 containers of 24 local and imported peanut butter brands collected from shops in Chipata, Mambwe, Petauke, Katete, and Nyimba districts and also in Lusaka from 2012 to 2014. For analysis, a sample included six containers of a single brand, from the same...