BACKGROUND Numerous syndromes with myopia and hearing loss have been described up to now. We present a family with pathologic myopia, corneal dystrophy, and deafness distinct from these syndromes. CASES Ten patients in the same Turkish family were evaluated by ophthalmologic, audiologic, physical, radiologic, genetic, serologic, and biochemical examinations. OBSERVATIONS Ophthalmic examinat...

PURPOSE: Although previous studies suggest that orthokeratology contact lens wear slows eye growth in children with progressing myopia, some limitations in the methodology employed have become evident. Furthermore, the safety of this modality of visual correction has not been assessed. The study “Myopia Control with Orthokeratology Contact Lenses in Spain” (MCOS) is being conducted to compare a...

PURPOSE Despite the plethora of experimental myopia animal studies that demonstrate biochemical factor changes in various eye tissues, and limited human studies utilizing pharmacologic agents to thwart axial elongation, we have little knowledge of the basic physiology that drives myopic development. Identifying the implicated genes for myopia susceptibility will provide a fundamental molecular ...

PURPOSE To compare axial length growth between white children with myopia wearing orthokeratology contact lenses (OK) and distance single-vision spectacles (SV) over a 2-year period. METHODS Subjects 6 to 12 years of age with myopia -0.75 to -4.00 diopters of sphere (DS) and astigmatism ≤1.00 diopters of cylinder (DC) were prospectively allocated OK or SV correction. Measurements of axial len...

INTRODUCTION Anomalies of the refractive state of the eye are the commonest cause of defective vision. PURPOSE To study the relationship between uncorrected visual acuity and refractive error in myopia in children, the prevalence of disparity between them and to find out the possible explanation for it. MATERIALS AND METHODS 100 eyes of 50 myopic children were studied and analyzed to study ...

BACKGROUND Due to its high prevalence and associated sight-threatening pathologies, myopia has emerged as a major health issue in East Asia. The purpose was to test the impact on myopia development of a school-based intervention program aimed at increasing the time student spent outdoors. METHODS A total of 3051 students of two primary (grades 1-5, aged 6-11) and two junior high schools (grad...

PURPOSE To determine whether the muscarinic antagonist atropine effectively reduces or prevents experimentally induced myopia via a nonaccommodative mechanism. METHODS Chicks were monocularly deprived (MD) of pattern vision by placement of a translucent occluder over the left eye. In two of the three MD groups, chicks received a series of intravitreal injections of atropine (n = 8) or saline ...

Background: High myopia (defined as of -6D or more) is one the main causes visual impairment worldwide. always accompanied by pathological structural changes such axial elongation, posterior staphyloma, lacquer crack formation, thinning retina and choroid, choroidal neovascularization.
 Aims Objectives: The purpose this study was to examine fundus in eyes with high myopia.
 Materials ...

PURPOSE It is well known that the dopaminergic signaling pathway plays a pivotal role in the control of axial elongation. Much research has shown that retinal dopamine (DA) is decreased in experimental myopia, but the exact alteration in DA quantity underlying the myopia model induced by flickering light (FL) has not yet been fully elucidated. Therefore, in this study, we first attempted to pro...