dementia is defined as significant acquired cognitive impairment in one or more cognitive domains that represents a significant decline from previous baseline and interferes with independence in daily activities. autoimmune dementia is a term that has been used to describe a steroid-responsive autoimmune disorder characterized by a rapidly progressive dementia with a fluctuating course. even co...

There is a complex bidirectional relationship between rheumatic diseases and cancer. Certain diseases, in particular dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, Sjogren’s syndrome, sclerosis, on the one hand, are associated with an increased risk of malignant neoplasms against background disease, contributing to cancer due immunological stimulation. On oth...

aim : the aim of this study was to review our experience with gestations in autoimmune hepatitis patients. background : there are only limited data describing pregnancy in patients with autoimmune hepatitis. patients and methods : retrospective analysis of pregnancies with autoimmune hepatitis followed in centro hospitalar do porto, portugal in the last ten years. results : we reported nine pre...

3. SOLOMAN DH, KAVANAUGH AJ, SCHUR PH: American College of Rheumatology Ad Hoc Committee on Immunologic Testing: Evidence-based guidelines for the use of Immunologic tests: antinuclear antibody testing. Arthritis Rheum 2002; 47: 434-44. 4. GORDON T. ISENBURG D: The Endocrinologic Associations ofthe Autoimmune Rheumatic Diseases. Semin Arthritis Rheum 1987; 17: 58-70. 5. TEKTONIDOU MG, ANAPLIOUT...

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are relatively common, severe autoimmune diseases. These two diseases represent examples of a larger number of autoimmune diseases such as multiple sclerosis, Crohn’s Disease, ulcerative colitis, juvenile diabetes, and psoriasis, among many others that collectively affect millions of Americans. Basic and clinical studies have show...

Autoimmune cholangitis (AIC) or autoimmune cholangiopathy is a chronic inflammation of liver and a variant syndrome of autoimmune hepatitis (AIH). We present a case of an adult female who had biochemical features of cholestasis and transaminasemia but aminotransferases were not in the hepatitis range and had histological evidence of bile duct injury which was subsequently diagnosed as autoimmun...

Celiac disease is an autoimmune disorder primarily targeting the small bowel, although extraintestinal extensions have been reported. The autoimmune processes can affect the liver with manifestations such as primary biliary cirrhosis and autoimmune hepatitis. We describe a 61-year-old woman with celiac disease and an increased levels of aminotransferases. The persistence of increased levels of ...

Abstract More than 80 diseases are currently classified as autoimmune, with a rising prevalence throughout the world. Systemic lupus erythematosus (SLE) is systemic autoimmune disorder, but exact pathogenesis of SLE remains elusive. Currently available treatment strategies offer only possibility for disease remission making it essential to develop more effective and safer treatment. Recently MS...

In recent years, major advances have been achieved in the understanding of pulmonary arterial hypertension (PAH) patho-physiology. Associated pulmonary arterial hypertension (APAH) can occur in a variety of other conditions and circumstances including a number of systemic autoimmune diseases. As with PAH in general, clinical symptoms of APAH in systemic autoimmune diseases are unspecific. In ad...

N Engl J Med 2006;354:54-66. Copyright © 2006 Massachusetts Medical Society. A utoimmune hepatitis is a generally progressive, chronic hepatitis of unknown cause that occurs in children and adults of all ages. Occasionally, it has a fluctuating course, with periods of increased or decreased activity. The diagnosis is based on histologic abnormalities, characteristic clinical and biochemical fin...