Background: Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune neurological disorder that is characterized by optic neuritis and longitudinally-extended transverse myelitis lesions in spinal segments. Magnetic Resonance Imaging (MRI) findings are part of the diagnostic process in NMOSD patients, and abnormal lesion patterns may cause deviation from a correct diagnosis.  Clinical P...

Introduction SIAE is involved in the maintenance of immunological tolerance through negative regulation of Β-cell receptor (BCR) signaling. Recent evidences, though conflicting, indicate that rare loss-of-function SIAE variants are associated with susceptibility to various autoimmune diseases. Advances in understanding JIA pathophysiology have led to the consensus that systemic JIA (SJIA) is an...

Collectively, autoimmune diseases constitute a major, unmet, clinical challenge. Although no single autoimmune disorder is highly prevalent, there are over 80 of them, and 20% of the population is aVected; approximately 75% of patients are women. Because these diseases are generally incurable and diYcult to manage, there is a pressing need for novel approaches to their treatment. For reasons de...

Autoimmune pancreatitis is a recently described chronic inflammatory disease of the pancreas which appears to be part of a systemic disorder characterized by a lymphoplasmacytic infiltrate in affected organs that is rich in IgG4 positive cells. The inflammatory component of the disease appears to resolve with steroid treatment, though relapses do occur. Here we briefly discuss the role of stero...

Anetoderma is a rare elastolytic disorder characterized by circumscribed areas of flaccid skin due to the loss of elastic tissue in the dermis. Primary anetoderma is frequently observed in patients with autoimmune diseases or abnormalities especially with antiphospholipid antibodies with or without antiphospholipid syndrome. In this case report we discuss a patient with primary anetoderma with ...

a change in proinflammatory plasma cytokine profile of patients with juvenile dermatomyositis correlating with disease activity Juvenile dermatomyositis ( JDM) is a rare autoimmune disorder, affecting mainly muscles and skin. The mainstay of treatment is high dose corticosteroids, combined with other immunosuppressive drugs. In about 30% of patients, the disease cannot be controlled despite mul...

Our patient developed Riedel's thyroiditis soon after having an exacerbation of multiple sclerosis (MS). MS has been associated with other autoimmune diseases, including thyroiditis, and both Hashimoto's thyroiditis and subacute thyroiditis have been described in connection with MS. Yet, we are not aware of any other patient reported to have concomitant MS and Riedel's thyroiditis. The associat...

Vitiligo is an autoimmune depigmentation disorder that is estimated to affect about .5% of the worldwide population. Half of all cases begin in childhood. A variety of advances occurred in the past two decades that have enhanced the management of childhood vitiligo. This contribution reviews recent advances in vitiligo, including a better understanding of the pathogenesis and autoimmune comorbi...

Background: Alopecia areata is one of the most common autoimmune diseases. The pathobiology of this chronic, relapsing hair-loss disorder is not fully understood, and the available therapies are disappointing. Objective: Currently considered a T-cell-mediated autoimmune disease, in which the gradual loss of protection provided by immune privilege of the normal hair follicle plays an important r...

Ulcerative colitis is an autoimmune disorder leading to chronic intestinal inflammation. It can present with a wide range of associated extra-intestinal manifestations. We present a case of an 18-year-old man diagnosed with ulcerative colitis, autoimmune hemolytic anemia and primary sclerosing cholangitis during the same hospitalization. The unique triad of these diseases gives important clues ...