inflammatory bowel diseases are one of the important reasons of the referral to gi practitioners in our country and ulcerative colitis is the more frequent type of these disease in iran. in this study 200 cases of ulcerative colitis, which has been referred to imam khomeini hospital during that last 5 year, were studied. data was collected using the patient's records and face to face inter...

Pemphigus vulgaris (PV) is an infrequent autoimmune bullous disease involving the skin and mucous membranes, which is rare in pediatrics. Although the main therapy for childhood PV are steroids, immunosuppressive drugs are often needed to control the disease. We report the case of an 11-year-old Caucasian boy who presented with a 10 months history of PV unresponsive to steroids and to intraveno...

Autoimmune bullous disorders are a group of severe skin diseases characterized clinically by blisters and erosions of skin and/or mucous membranes. A hallmark of these disorders is the presence of IgG and occasionally IgA autoantibodies that target distinct adhesion structures of the epidermis, dermoepidermal basement membrane, and anchoring fibrils of the dermis. This Review focuses on the pot...

about 3 decades ago cd6 identified as one of the first antigens expresses on the majority of t cells and a subset of b cells. cd6 regulates cellular adhesion migration across the endothelial and epithelial cells. in recent years researches indicate its role in pathogenesis of autoimmune diseases. many researches have been done in recent years to block cd6 by cd6 mono clonal antibodies, ior-t1 a...

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease in which cutaneous lesions occur in 72%-85% of patients. Objective: This study was conducted to determine the pattern and incidence of skin lesions in SLE patients in Ahwaz. Patients and Methods: Thirty patients with SLE fulfilling the clinical and laboratory criteria of the American Rheumatism Association who were admitted...