نتایج جستجو برای: autoantibody

تعداد نتایج: 6541  

Journal: :Current opinion in chemical biology 2014
Francesc Galban-Horcajo Susan K Halstead Rhona McGonigal Hugh J Willison

Humans with autoimmune peripheral neuropathies frequently harbour serum antibodies to single glycosphingolipids, especially gangliosides. Recently it has been appreciated that glycolipid and lipid complexes, formed from two or more individual species, can interact to create molecular shapes capable of being recognised by these autoantibodies whilst not binding to the single individuals. As a re...

ژورنال: Medical Laboratory Journal 2012
Alizadeh, Sh., , Bazzazi, H., , Davarpanah, M R, , Govahi, M., , Jahazi, A., , Mokaram, R., , Naeimi Tabiee, E, ,

Abstract Background and objectives: Recurrent miscarriage (RM) is one of the most common reproductive disorders, generally considered to be the loss of three or more pregnancies before viability. One of the causes of this disorder is the immunological factors such as autoantibodies associated with anti-phospholipid syndrome. Material and Methods: this case-control study was conducted on ...

M GHARAGOUZLOU, M NAKHJEVANI, S RAFIEI,

32 patients (19 female. 13 male)• suffering from Graves' disease with exophthalmus and five without exophthalmus were studied for various autoantibodies including anti-thyroglobulin (ATAB). anti-microsomal antibody (AMAB). anti-parietal antibodies (APAB) and also circulating immune complex (CrC). 43 normal subjects were tested concurrently. Immunofluorescent technique was employed for auto...

Journal: :The European respiratory journal 2009
M Luisetti G Rodi C Perotti I Campo F Mariani E Pozzi B C Trapnell

Whole lung lavage (WLL) is currently the standard therapy for pulmonary alveolar proteinosis (PAP). Nevertheless, some PAP patients respond poorly to WLL or require it frequently. The present paper reports a patient with autoimmune PAP with persistent disease despite three WLL treatments over 10 months. Plasmapheresis with ten 1.5-L plasma exchanges was performed, which lowered the serum granul...

Journal: :Journal of neurology, neurosurgery, and psychiatry 1982
T Kitahara K Okumura A Semba A Yamaura H Makino

The genetic and immunologic abnormalities associated with the pathogenesis of moya-moya were assessed in 23, 13 children and 10 adults with angiographically diagnosed moya-moya. In HLA-A, -B, -C stereotyping, an association was found of AW24, BW46, and BW54 with relative risks of 3.83, 6.50, and 3.58 respectively. Natural T cell toxic autoantibody was detected by FACS analysis in sera from five...

2013
Mohammed I. Hawa Hubert Kolb Nanette Schloot Huriya Beyan Stavroula A. Paschou Raffaella Buzzetti Didac Mauricio Alberto De Leiva Knud Yderstraede Henning Beck-Neilsen Jaakko Tuomilehto Cinzia Sarti Charles Thivolet David Hadden Steven Hunter Guntram Schernthaner Werner A. Scherbaum Rhys Williams Sinead Brophy Paolo Pozzilli Richard David Leslie

OBJECTIVE Specific autoantibodies characterize type 1 diabetes in childhood but are also found in adult-onset diabetes, even when initially non-insulin requiring, e.g., with latent autoimmune diabetes (LADA). We aimed to characterize adult-onset autoimmune diabetes. RESEARCH DESIGN AND METHODS We consecutively studied 6,156 European diabetic patients attending clinics within 5 years of diagno...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010
Stefanie Strobel Peter F Hoyer Christoph J Mache Endre Sulyok Wei-Shih Liu Heiko Richter Martin Oppermann Peter F Zipfel Mihály Józsi

BACKGROUND Atypical haemolytic uraemic syndrome (aHUS) is associated with defective complement regulation. Recently, an autoimmune aHUS form has been described that is associated with complement factor H (CFH) autoantibodies. The aim of this study was to address the pathologic relevance of CFH autoantibodies in aHUS. METHODS CFH autoantibodies were identified and antibody levels were analysed...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Erika S Horta Vanda A Lennon Daniel H Lachance Sarah M Jenkins Carin Y Smith Andrew McKeon Christopher Klein Sean J Pittock

PURPOSE Clustering of neural autoantibodies in patients with paraneoplastic neurologic disorders may predict tumor type. A mathematical analysis of neural autoantibody clusters was performed in 78,889 patients undergoing evaluation for a suspected paraneoplastic autoimmune neurologic disorder. Tumor predictive autoantibody profiles were confirmed in sera from patients with histologically proven...

Journal: :Blood 1991
R Weimer V Daniel R Zimmermann K Schimpf G Opelz

To investigate whether autoantibodies against CD4-positive lymphocytes might induce helper dysfunction, autoantibody formation and T-cell function was examined simultaneously in 61 hemophilia patients. Twenty patients were human immunodeficiency virus (HIV)-negative, 26 HIV-positive stage CDC II or III, and 15 were HIV-positive stage CDC IV. T lymphocytes, CD4-positive, or CD8-positive T subset...

2011
Barbara M. Brooks-Worrell Jessica L. Reichow Amit Goel Heba Ismail Jerry P. Palmer

OBJECTIVE Islet autoimmunity has long been recognized in the pathogenesis of type 1 diabetes and is becoming increasingly acknowledged as a component in the pathogenesis of type 2 diabetes. Islet reactive T cells and autoantibodies have been demonstrated in type 1 diabetes, whereas islet autoimmunity in type 2 diabetes has been limited to islet autoantibodies. In this study, we investigated whe...

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