Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management. Gonadal impairment has been f...

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Serono Symposia International convened an expert panel to review the impact of environmental influences on the regulation of pubertal onset and progression while identifying critical data gaps and future research priorities. An expert panel reviewed the literature on endocrine-disrupting chemicals, body size, and puberty. The panel concluded that available experimental animal and human data sup...

Integration of kDNA sequences within the genome of the host cell shown by PCR amplification with primers to the conserved Trypanosoma cruzi kDNA minicircle sequence was confirmed by Southern hybridization with specific probes. The cells containing the integrated kDNA sequences were then perpetuated as transfected macrophage subclonal lines. The kDNA transfected macrophages expressed membrane an...

The objective of this chapter is to analyze empirically the potential dynamics of the relationship among the size of the shadow economy, fiscal burden and the official economy. The empirical analysis is based on the size estimates of the shadow economy in 17 developed and 11 transition economies of Europe for the period 1999-2013 and in 16 economies of Middle East and North Africa for the perio...

This patient presents a classic case of severe warm autoimmune hemolytic anemia (WAIHA). Criteria for that diagnosis include evidence of autoantibody directed against the RBCs as well as classic evidence of hemolysis. The former is evident in the form of a positive DAT due to IgG and complement coating of the RBCs. Reactivity with all cells in the antibody identification panel is typical of aut...

This study investigates the effect of various types trade impediments on Indonesia's flows. We categorize tariff measures, non-tariff measures (NTMs), and lack facilitation into at-the-border behind-the-border barriers. A gravity model is applied to a panel dataset covering 177 partners from 2007 2016. shows that protection remains high, particularly due increasing use NTMs. Furthermore, also c...

auto-reactive cells-mediated immune responses are responsible for the current tissue damages during autoimmunity. accordingly, functional modulation of auto-reactive cells has been a pivotal aim in many of recent studies. in the current study, we investigated the possibility for insertion of regulatory molecules onto auto-reactive cells through exosomal nano-shuttles as a novel approach for phe...

auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive t cells, and an inborn error of innate immunity. a narrative literature review was carried out of studies related to auto-inflammatory syndromes ...

Autologous hematopoietic cell transplantation (HCT) followed by nonmyeloablative allogeneic HCT (auto/alloHCT) provides cytoreduction and graft-versus-myeloma effects. We report on long-term outcomes of 102 patients with multiple myeloma who received auto/alloHCT with a median follow-up of 6.3 years. Treatment consisted of high-dose melphalan and autograft followed by 2-Gy total body irradiatio...