Respiratory sinus arrhythmia (RSA) is a cyclical variation in heart rate during breathing, where the heart rate increases during inspiration and decreases during expiration. RSA and the electroencephalogram (EEG) were monitored in 10 patients undergoing elective surgery with isoflurane and nitrous oxide in oxygen anaesthesia after induction with propofol. All patients were subject to controlled...

PURPOSE These studies were intended to resolve the conflict between the reasonable inference from the scientific literature that atropine might alter neuromuscular fade and the expectation from informal clinical experience that it does not. METHODS We examined the effect of a high concentration of atropine (20 microM) on moderate neuromuscular block and fade produced by d-tubocurarine (dTC). ...

The bronchodilator potencies of inhaled atropine sulphate and atropine methonitrate have been compared either alone or in combination with fenoterol in a group of adult asthmatic patients. A cumulative dose response study showed that 2 mg of atropine sulphate produced near maximum bronchodilatation. A larger dose of 4 mg was used in comparing the potency of this drug with 2 mg of atropine metho...

BACKGROUND Muscarinic receptors (mAChRs) of the preoptic and anterior hypothalamus areas (POA-AHA) regulate ovulation in an asymmetric manner during the estrous cycle. The aims of the present study were to analyze the effects of a temporal blockade of mAChRs on either side of the POA-AHA performed in diestrus-2 rats on ovulation, the levels of estradiol, follicle stimulating hormone (FSH) and l...

On September 22, 1980 Iraqis attacked Iran's air bases and simultaneously entered Iran with six army divisions on three fronts and occupied a vast part of Iranian territories. At that time, Iraqis did not have chemical warfare. But in time, they began to develop an intensive research program to produce and store chemical weapons and used the war fields to test and perfect their chemical warfare...

Condensed tannins (CTs) extracted from various plants have been shown to possess antioxidant, antidiabetic, anthelmintic, anti-palatable and anti-diarrhea activity. Black currant (Ribes nigrum L.), a native plant of northern Europe Asia, is rich in phenolic compounds, including CTs. Among the biological activities CTs, their astringent property likely affect gastrointestinal motility. This stud...

The roles of cyclic AMP and cyclic AMP-dependent protein kinase in the contractile and metabolic responses to neural stimulation were studied in the bullfrog heart perfused in situ. The interaction of parasympathetic and sympathetic nerves in the regulation of myocardial cyclic AMP, cyclic AMP-dependent protein kinase, and phosphorylase also was studied. Stimulation of the left vagosympathetic ...

Up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (M1, M2, M3 and M4). In our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. Isolated preparations of longitudinal and circular muscle layers from human stomach were used. Acetylcholine, bethanechol, carbachol, pilocarpine and AHR -602 produced concen...