Atherosclerotic lesions were induced in rhesus monkeys by feeding a high-saturated fatty acid and high-cholesterol diet. After 5.4 years the extent of fatty streaks and raised lesions was evaluated in one group of animals (group P) by visual estimation in 10 arterial segments and chemically in four arterial segments. The remaining animals were switched to a basal regression diet low in choleste...

BACKGROUND Hyperhomocysteinemia is associated with increased risk of atherosclerotic and thrombotic vascular disease. In many patients, hyperhomocysteinemia can be treated or prevented by dietary supplementation with B vitamins, but the clinical benefit of B vitamins for the prevention of vascular disease has not been proven. METHODS AND RESULTS Using an atherogenic diet that produces both hy...

Purslane extract in the form of ethanolic formulation is rich in polyphenols, flavonoids and anthocyanin, w-3 fatty acids and melatonin. The present study was designed to investigate the anti-obesity and anti-diabetic effects of purslane using obese diabetic rats. The rats received either regular diet, high-fat diet or high-fat diet with additional purslane (150 and 300 mg/kg body weight) for 8...

OBJECTIVE Hepatic ATP binding cassette transporter A1 (ABCA1) expression is critical for maintaining plasma high-density lipoprotein (HDL) concentrations, but its role in macrophage reverse cholesterol transport and atherosclerosis is not fully understood. We investigated atherosclerosis development and reverse cholesterol transport in hepatocyte-specific ABCA1 knockout (HSKO) mice in the low-d...

objectives the aim of this study was to examine the effect of flaxseed on gene expression of intestinal transporters: niemann-pick c1 like 1 (npc1l1), atp-cassette binding proteins g5 (abcg5) and g8 (abcg8). methods animals were randomly divided into 3 groups 8 rats in each group: group1; normal diet, group2; diabetic rats, and group3; diabetic rats + 4% (w/w) flaxseed. after one-month rats wer...

OBJECTIVE Mitogen-activated protein kinase phosphatase-1 (MKP-1) is one of several oxidized-l-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC)-induced genes identified in human aortic endothelial cells (HAEC). We previously reported that MKP-1 activity is required for Ox-PAPC-mediated endothelial/monocyte interactions; however, an in vivo role of MKP-1 in atherogenesis ...

PURPOSE To determine the effect of a statin (simvastatin) on the ultrastructure and function of the RPE, Bruch's membrane (BM), and photoreceptor interface in a high-fat atherogenic mouse model of thickened BM. METHODS Wild-type C57BL/6 mice (6-weeks old) were divided into three study groups according to their diet and treatment given; Group 1, normal chow diet-fed mice; Group 2, high fat die...