BAP is a publicly available infrastructure for performing program verification and analysis tasks on binary (i.e., executable) code. In this paper, we describe BAP as well as lessons learned from previous incarnations of binary analysis platforms. BAP explicitly represents all side effects of instructions in an intermediate language (IL), making syntaxdirected analysis possible. We have used BA...

Human colon carcinoma cells (HCT116) differing in p53 status were exposed to benzo(a)pyrene (BaP) or anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (BPDE) and their gene expression responses compared by complementary DNA microarray technology. Exposure of cells to BPDE for up to 24 h resulted in gene expression profiles more distinguishable by duration of exposure than by p53 status, al...

The biodegradation of benzo[a]pyrene (BaP) by using Polyporus sp. S133, a white-rot fungus isolated from oil-contaminated soil was investigated. Approximately 73% of the initial concentration of BaP was degraded within 30 d of incubation. The isolation and characterization of 3 metabolites by thin layer chromatography, column chromatography, and UV-vis spectrophotometry in combination with gas ...

It is believed that the formation of DNA adducts is an essential initial step in carcinogenesis. To better understand this initial step and its relationship to cancer, this study primarily focuses on benzo(a)pyrene (BaP), a highly carcinogenic model polycyclic aromatic hydrocarbon (PAH) and an ubiquitous environmental contaminant. The objective of this dissertation was to identify and quantify ...

A new technique to predict concentrations of benzo[a]pyrene (BaP) in ambient air during periods of lost data has been developed and tested. This new technique is based on the relationship between ambient temperature and BaP concentration observed at individual monitoring stations over many years. The technique has been tested on monthly data of BaP concentrations in PM10 at individual monitorin...

Sister chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes has been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genotoxins is benzo[ ]pyrene (BaP). We studied the ability of BaP to induce SCE and CA in 16 glutathione S-transferase M1 (GSTM1)-positive and 15 GSTM1-null individuals by analyzing 72-h whole-blood lymph...

Previous research has shown that persons with a higher level of the broad autism phenotype (BAP) experience deficits in empathy. The aim present study is to investigate multivariate relationship between BAP and different aspects In sample 293 university students, we explored following empathy: fantasy, empathic concern, perspective taking, personal distress. was measured using Broad Autism Phen...

B cell antigen receptors (BCRs) are multimeric transmembrane protein complexes comprising membrane-bound immunoglobulins (mIgs) and Ig-alpha/Ig-beta heterodimers. In most cases, transport of mIgs from the endoplasmic reticulum (ER) to the cell surface requires assembly with the Ig-alpha/Ig-beta subunits. In addition to Ig-alpha/Ig-beta, mIg molecules also bind two ER-resident membrane proteins,...

BACKGROUND Benzo(a)pyrene (BaP), naphthalene (NPh), phenanthrene (Phe), benzo(a)antharacene (BeA), and benzo(b)fluoranthene (BeF) are known carcinogenic polyaryl hydrocarbons (PAHs) present in cigarette smoke. This study was designed to examine the relative effect of these constituents on the cytotoxicity of monocytic cells and the possible mechanism of PAH-mediated cytotoxicity. METHODS We e...

Benzo[a]pyrene (BaP) is a genotoxic carcinogen and a neurotoxicant. The neurotoxicity of BaP is proposed to arise from either genotoxicity leading to neuronal cell death, or perturbed expression of N-methyl-d-aspartate receptor (NMDAR) subunits. To explore these hypotheses, we profiled hippocampal gene expression of adult male Muta(™) Mouse administered 0, 1, 35, or 70 mg BaP/kg bw per day by o...