Background: To evaluate the effect of aspirin on preeclampsia and fetal growth restriction (FGR) in obese pregnant women. Methods: A randomized clinical trial with 187 participants. Participants were allocated to either an intervention (aspirin; n=89) or control (placebo; n=98) group. In two groups, intervention was done from 13-20 until 34 weeks of pregnancy. Outcomes were preeclampsia and FG...

Resistance to aspirin and its cytotoxicity significantly limits its therapeutic applications. Nano-liposomal encapsulation of aspirin can reduce its cytotoxicity. In this study, aspirin encapsulated nano-liposomes (AS-NL) was prepared and its performance in drug delivery and cytotoxicity was evaluated. The effects of two independent variables including: number of freeze/thawing cycles and conce...

at present the only available management for food allergy is avoidance; however, abstaining from allergic foods can affect the quality of life. oral immunotherapy (oit) is an efficient method for increasing tolerance towards food allergens. the aim of this study was desensitizing patients above five years of age with wheat allergy and evaluating the safety and efficacy of oit for children with ...

allergic asthma is the most common acute inflammatory airway disorder and their incidence population has exploded in the last years, being estimated that over 300 million people worldwide have the condition. here, we present a brief overview of relationship of allergic asthma with diet and food intake. several studies have shown that most asthma cases are due to an allergic immune response to e...

BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) are reported to be the second most common cause of drug hypersensitivity. In 2011, experts from the EAACI/ENDA group and GA(2)LEN proposed a new classification system for NSAID hypersensitivity. The aim of this study was to classify a patient cohort with a history of NSAID hypersensitivity according to this system. METHODS Patients wit...

Food-dependent exercise-induced anaphylaxis (FDEIAn) is induced by different types and various intensities of physical activity, and is distinct from food allergies. It has been shown that consumption of allergenic food followed by exercise causes FDEIAn symptoms. Intake of allergenic food or medication before exercise is a major predisposing factor for FDEIAn. Urticaria and severe allergic rea...

BACKGROUND The significance of Candida albicans as an allergen is still unclear. This study aimed at investigating the clinical features of patients monosensitized to Candida. METHODS Thirty-four adult patients monosensitized to the yeast Candida albicans selected from a population of >7000 subjects and referred for suspect respiratory allergy were studied. Ninety subjects monosensitized to d...

UNLABELLED Advances in medical and dental techniques have led to a growing aged population living with complex medical conditions. This study focuses on the detection of medically compromised dental patients by means of a validated patient-administered medical risk-related history questionnaire. MATERIALS AND METHODS We used the questionnaire EMRRH (European Risk Related Medical History) in o...

Aspirin sensitivity is relatively frequent and can be a major problem in patients who need percutaneous coronary intervention and stenting with subsequent dual antiplatelet therapy. Desensitization is often the therapy in these patients, but this can prolong the time to revascularization significantly. Rapid oral aspirin desensitization protocols have been described since 2000. However, data ar...