We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged...

introduction: n-methyl-d-aspartate (nmda) receptors play a pivotal role in the development of tolerance and physical dependence to opiates. activation of nmda receptors involves the induction of long term potentiation (ltp) in hippocampus. our previous study suggested that chronic oral administration of morphine enhanced nmda dependent ltp in the ca1 area of hippocampal slices of rats. the pres...

Memory of even the briefest event can last a lifetime. Thus, learning and memory require neuronal mechanisms that allow rapid, yet persistent, changes to brain circuits. Hippocampal neuropsychology, synaptic and cellular electrophysiology, pharmacology, and molecular genetics converge and begin to reveal these mechanisms. Lesions of the hippocampus profoundly impair memory for recent events in ...

previous studies indicated that endurance exercise decreases levels of liver enzymes. the aim of this study was to determine the effect of endurance exercise on liver enzymes in eight weeks in iranian women who are stopping the drug with methadone. sixty iranian women prisoners including 30 cases as experimental group and 30 volunteers served as control. the mean age, height, weight, percent of...

GAZZALEY, A. H., M. M. THAKKER, P. R. HOF, J. H. MORRISON. Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. NEUROBIOL AGING 18(5) 549–553, 1997.—The perforant path, which consists of the projection from the layer II neurons of the entorhinal cortex to the outer molecular layer of the dentate gyrus, is a critical circuit involved in learning and memory formation. A...

The functional roles played by metabotropic glutamate receptors in the neostriatum is just beginning to be examined. One possibility, raised by previous studies, is that metabotropic glutamate receptors act to modulate responses mediated by ionotropic glutamate receptors. In the present study, we examined this possibility in a neostriatal brain slice preparation using intracellular recording an...

OBJECTIVES To report the clinical, laboratory, and radiographic features and the response to plasmapheresis in a patient with encephalopathy, opsoclonus, and myoclonus whose cerebrospinal fluid was positive for N-methyl-D-aspartate receptor-IgG. DESIGN Case report. SETTING St Marys Hospital, Rochester, Minnesota. PATIENT A 27-year-old woman with a history of episodic migraine developed su...