Aspartame (APM) is a widely used artificial sweetener consumed by hundreds of millions of people around the world . It is found in more than 6,000 products, including soft drinks, chewing gum, candy, yoghurt, tabletop sweeteners and some pharmaceuticals such as vitamins and sugar-free cough drops. Dietary surveys, performed among APM consumers, have shown that the average APM daily intake in th...

Background The use of non-caloric sweeteners can interfere in the regulation of appetite, promoting greater food intake and weight gain. In previous data, our results showed that animals who consumed yogurt with saccharin and aspartame had a increase in weight compared to the group using sucrose. However, as the total calorie intake was similar between the groups, we speculated that weight gain...

Background Colloidal silica is an inorganic substance widely used as excipient in pharmaceutical preparation. It acts as a vehicule to increase the absorption of many oral drug formulations. Many excipients have been reported to induce drug hypersensitivity such as tartrazine, aspartame, benzalkonium chloride, sodium metabisulphite, propyl gallate. However, colloidal silica has never been repor...

Neotame is a dipeptide methyl ester derivate. Its chemical structure is N-[N-(3,3dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester. It is intended for use in food as a sweetener and flavour enhancer. Neotame has a sweetness factor approximately 7000 to 13000 times greater than that of sucrose and approximately 30 to 60 times greater than that of aspartame, depending upon the food appl...

EFSA is implementing evidence-based risk assessments for the re-evaluation of certain sweeteners. The aim this work was to ensure that, as part preparatory done by support its Panel on Food Additives and Flavourings (FAF) in reaching conclusions safety permitted food additives, relevant information environmental risks associated with use artificial sweeteners are identified. In context process ...