The inhibiting effect of ascorbic acid, citric acid and sodium chloride on Polyphenoloxidase (PPO) of Golden Delicious apple cubes was studied. Dipping in ascorbic acid (0.2-10 g/L range) and in NaCl (0.2-1 g/L range) solutions for 5 min increases the PPO activiry. Citric acid solutions (0.2-10 g / L range) have little or no inhibition of PPO. A 90-100% PPO inhibition was obtained with a 5 min ...

The influence of ascorbic acid administration via drinking water at a dose of 15 mg/l over a period of 7 days on the pharmacokinetics of oleandomycin in chickens, musk ducks and Japanese quails was investigated. After ascorbic acid oleandomycin elimination, half-life was longer. Oleandomycin bioavailability in chickens and quails after per os application was increased with ascorbic acid. Inters...

The influence of L-ascorbic acid at 40 degrees C incubation on the subfragment-1 and rod regions, prepared by chymotryptic digestion of myosin, and myosin was investigated by SDS-polyacrylamide gel electrophoresis and transmission electron microscopy respectively. It was observed that L-ascorbic acid acted more readily on the subfragment-1 region of myosin. Further, circular dichroism measureme...

Quantitative studies of collagen formation by chick embryonic lung tissue grown in media deficient in, or completely lacking, ascorbic acid have been carried out. Cell growth and collagen formation in such cultures can proceed almost normally in media lacking ascorbic acid. Ascorbic acid in combination with whole embryo extract, dialyzed media, or synthetic mixture number 703 was found to have ...

The effect of ascorbic acid on cancer has been a subject of great controversy. This is a follow-up review of the 1979 article by Cameron, Pauling, and Leibovitz published in Cancer Research. In this updated version, the authors address general aspects of ascorbic acid and cancer that have been presented before, while reviewing, analyzing, and updating new existing literature on the subject. In ...

Ascorbic acid treatment in arsenic trioxide treated rats increased arsenic excretion, inhibited lipid peroxidation, improved GSH status, regulated GSSG turnover and also restored glutathione-S-transferases activity in liver and kidney. Suitable mechanisms leading to ascorbic acid protection have been discussed. Upregulation of GSH dependent enzymes was found to be necessary for a protective eff...

L-ascorbic acid is an essential cofactor for lysyl hydroxylase and prolyl hydroxylase, enzymes essential for collagen biosynthesis. In addition, L-ascorbic acid preferentially stimulates collagen synthesis in a manner which appears unrelated to the effect of L-ascorbic acid on hydroxylation reactions. This reaction is stereospecific and unrelated to intracellular degradation of collagen. The ef...

The importance of ascorbic acid for the metabolism of connective tissue substances, especially collagen, has been established by numerous investigators, using morphologic criteria (1). However, there have been few biochemical studies of this function of ascorbic acid with the exception of the recent analyses of Elster (2) and Robertson (3), which demonstrated that the maintenance of preformed c...

The fact that in experimental scurvy the concentration of ascorbic acid in the cellular elements of blood decreases more slowly than does the concentration in plasma (24) has led to the hypothesis that ascorbic acid might be bound’ to cellular protein (5, 6). There is, however, little direct evidence to support such a hypothesis. Saha, Majumdar, and Guha (7, 8) demonstrated the presence of boun...

Ascorbic Acid and Chronic Alcohol Consumption in the Guinea Pig. SUSICK, R. L., JR., ABRAM& G. D., ZURAWSKI, C. A., AND ZANNONI, V. G. (1986). Toxicol. Appl. Pharmacol. 84,329-335. Protection against the toxic effects of chronic alcohol consumption was observed in male guinea pigs maintained on a high-ascorbic-acid diet (vitamin C-deficient chow plus 2.0 mg ascorbic acid/ml drinking water) as c...