A nickel-catalyzed and benzoic acid-promoted direct sulfenylation of unactivated arenes using removable 2-(pyridine-2-yl)-isopropylamine as a directing group is described. This strategy provides an efficient access to valuable aryl sulfides with ample substrate scope and a high degree of functional group tolerance.

Protecting-group-independent cross-coupling of α-alkoxyalkyl- and α-acyloxyalkyltrifluoroborates with aryl and heteroaryl bromides is achieved through application of photoredox/nickel dual catalysis. Reactions occur under exceptionally mild conditions, with outstanding functional group compatibility and excellent observed tolerance of heteroarenes. This method offers expedient access to protect...

In recent years, it has become an urgent task to design new types of indole-based platform molecules for Nazarov-type cyclizations and develop organocatalytic synthesizing indole derivatives. To fulfill this task, in work, by changing the alkynyl terminal substituent from t-Bu aryl group, reactivity 3-alkynyl-2-indolylmethanols is modulated serve as competent substrates Brønsted acid-catalyzed ...

Studies on the palladium-catalyzed formation of aryl amines, aryl ethers and a-aryl carbonyl compounds from aryl halides are reported. These studies range from synthetic methodology, to detailed mechanistic analysis, to new methods one can use to screen for catalytic covalent bond formation. Improved methods for formation of aryl ethers and room temperature amination chemistry have resulted fro...

Title of Dissertation: DEVELOPMENT OF ARYL SILOXANE CROSSCOUPLING TECHNOLOGY AND ITS APPLICATION TO THE SYNTHESIS OF COLCHICINE AND ALLOCOLCHICINE DERIVATIVES William Michael Seganish, Doctor of Philosophy, 2005 Dissertation directed by: Professor Philip DeShong Department of Chemistry and Biochemistry One of the most versatile methods for the formation of aryl-aryl bonds is the palladium-catal...

The search for extremely sterically demanding monodentate amide ligands to access main group complexes in low-coordination numbers and highly reactive bonding modes is an area of intense research interest. The recent development of three classes of sterically demanding, monodentate amide ligands - the m-terphenyl anilides [N(R){C6H3Ar2-2,6}](-) (Ar = aryl, R = H, methyl, silyl), substituted car...

The mechanism of the previously developed cross-coupling reaction of aryl Grignard reagents with aryl halides was explored in more detail. Single electron transfer from an aryl Grignard reagent to an aryl halide initiates a radical chain by giving an anion radical of the aryl halide. The following propagation cycle consists entirely of anion radical intermediates.

We report the Pd-catalyzed α-arylation of α,α-difluoroketones with aryl and heteroaryl bromides and chlorides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)Cy2 as ligand. The combination of this Pd-catalyzed arylation and base-induced cleavage of the acyl-aryl C-C bond within the α-aryl-α,α-difluoroketone constitutes a one-pot, two-step procedure to synthesize...

in the present work, novel 7-aryl-10, 11-dihydro-7h-chromeno [4, 3-b]quinoline-6, 8(9h, 12h)-dione derivatives were synthesized by oxidation of 7-aryl-8, 9, 10, 12-tetrahydro-7h-chromeno[4, 3-b]quinoline-6, 8-diones in the presence of silica sulfuric acid/nano2 with yields of 64-74%. cytotoxic activity of synthesized compounds was assessed on three different human cancer cell lines (k562, ls180...