The heteroleptic calcium amides [{ArNC(Me)CHC(Me)NAr}Ca(NR(2))(THF)] (Ar=2,6-di-iso-propylphenyl, R=SiMe(3), Ph) and the homoleptic heavier alkaline earth amides, [M{N(SiMe(3))(2)}(2)] (M=Ca, Sr and Ba) are reported as pre-catalysts for the hydroamination of isocyanates.

The reaction of tertiary, secondary and benzylic alcohols with different nitriles in the presence of alumina-methanesulfonic acid (AMA) as a new reagent affords the corresponding amides in good yields (Table 1, 2). Conversion of 2,6-bis(hydroxymethyl)-4-halo anisoles into corresponding diamides in the range of 68-76% yields (Table 3) are also included in this paper.

The treatment of β,γ-unsaturated α-ketoesters with phenols in the presence of trityl chloride and 4 Å molecular sieves in refluxing trifluoroacetic acid afforded 4-aryl-2H-chromenes in high yields, in which a reverse of the regiochemistry of Jørgensen-Rutjes chromane synthesis was observed. The isolation of 4H-chromene intermediates, confirmed by single-crystal X-ray analysis, indicates that th...

A study of the reactions of several salicylaldimines (ortho-iminophenols) with Sn(NMe2)2 reveals that the sterics and electronics of the N-substituent play a principal role in determining the product mixture. Thus mono(chelate) tin(II) amides have only been isolated with bulky N-anilido substituents, including [2,4-X2-6-{CHN-2,6-iPr2C6H3}-C6H2O]Sn(-NMe2)]2, X = Cl, 1; X = I, 2 and [2,4-Cl2-6-{C...

By combining the scaffolds of UI-125 and Sorafenib, a series of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine moiety were designed and synthesized as novel DFG-out B-Raf(V600E) inhibitors. Among them, 20c-e, 20g and 21h displayed potent antiproliferative activities against melanoma A375 (B-Raf(V600E)) cell lines with IC50 values of 3.190, 2.276, 1.856, 1.632 μM and 1.839 μM, resp...

Peptoid molecules are biomimetic oligomers that can fold into unique three-dimensional structures. As part of an effort to advance computational design of folded oligomers, we present blind-structure predictions for three peptoid sequences using a combination of Replica Exchange Molecular Dynamics (REMD) simulation and Quantum Mechanical refinement. We correctly predicted the structure of a N-a...

Reactive oxygen species, along with reactive nitrogen species, may play an important role in the pathogenesis and progress of many diseases, including cancer, diabetes and sickle cell disease. It has been postulated that hydroxyurea, one of the main treatments in sickle cell disease, achieves its activity partly also through its antioxidant properties. A series of hydroxyurea derivatives of L- ...