This study describes a general chemoselective Suzuki–Miyaura coupling of polyhalogenated aryl triflates with the reactivity order C–Cl > C–OTf using Pd/L33 catalyst. The methine hydrogen and steric hindrance offered by alkyl bottom ring L33 were found to be key factors in chemoselectivity. With catalyst, wide range (hetero)aryl triflates, which independent substrates relative positioning compet...

For the first time, challenging atropo-enantioselective coupling of in-situ generated arynes and aryllithiums in presence a chiral ligand lithium was investigated. This preliminary study demonstrates feasibility this concept, by affording enantioenriched axially biaryls even case products showing high degree steric congestion around newly created aryl–aryl bond.

[reaction: see text] N-Aryl beta-amino esters were obtained by asymmetric hydrogenation of a new class of N-aryl beta-enamino esters. High conversions and up to 96.3% ee values were achieved with a Rh-TangPhos catalyst.

We synthesised aryl acetylene derivatives as versatile probes for labelling of oligonucleotides. RNA oligomers bearing an aryl acetylene molecule rapidly reacted with benzylazide derivatives under ligand-free click reaction conditions.

Chiral aryl vicinal diols were obtained in high ee and yield by asymmetric dihydroxylation of aryl olefins with tandem biocatalysts: one contains an enantioselective styrene monooxygenase, and the other contains a regioselective epoxide hydrolase.

A palladium-catalyzed desulfitative cyanation of arenesulfonyl chlorides and sodium sulfinates has been developed, providing aryl nitriles in moderate to excellent yields. It represents a facile procedure to access aryl nitriles.

Pd-catalyzed direct C-H arylation of unprotected purine nucleosides with aryl iodides at position 8 was developed to allow a straightforward single-step introduction of diverse aryl groups.

Aryl formates are efficient carbon monoxide sources in palladium-catalyzed esterification of aryl halides. The carbonylation readily proceeds at ambient pressure without the use of external carbon monoxide to afford the corresponding esters in high yields.

Hydroarylation reactions play a pivotal role in organic chemistry due to their versatility and efficiency. In the last 10 years, scientific production around this reaction has been very high, but its asymmetric version, results are less. mini review, selected literature examples considered draw attention directions of hydroarylation mediated by transition metal catalysts. The works were grouped...