OBJECTIVES The purpose of this study was to investigate the amount of fluid required and the sensitivity of the saline load test to identify an intra-articular arthrotomy of the elbow. METHODS A cadaveric study was conducted using 36 thawed, fresh-frozen forequarter amputations. An elbow arthrotomy was made in the posterocentral arthroscopic portal site with a 4.5-mm trochar. To confirm intra...

AIMS To evaluate the efficacy and safety of nitrous oxide-oxygen for children with juvenile idiopathic arthritis (JIA) undergoing intra-articular corticosteroid injection. METHODS A total of 55 consecutive patients with JIA undergoing intra-articular corticosteroid injection, using self administered nitrous oxide-oxygen for analgesia were studied. Patient, nurse, and parent pain scores were c...

Adhesive capsulitis of the shoulder joint is a common disorder characterized by gradual increase pain and limitation in range motion joint. The pathophysiological process involves fibrous inflammation capsule leading to capsular thickening contracture. Intra-articular corticosteroid injection commonly performed patients with adhesive capsulitis. However, there no consensus as best site. Cortico...

BACKGROUND Several medications are commonly injected intra-articularly for postoperative analgesia after arthroscopic knee surgery. Among the potentially efficient substances, magnesium could be of particular interest through its NMDA-receptor blocking properties. METHODS A total of 60 patients undergoing arthroscopic knee surgery were randomly and double-blindly assigned to two groups to rec...

This study investigated the effect of human placenta extract (HPE) on cartilage degradation in vitro MG-63 cells, articular cartilage explants, and in vivo monoiodoacetate (MIA)-induced osteoarthritis (OA). Matrix metalloproteinase (MMP)-2 activity was measured in HPE-treated osteoblastic MG-63 cells. Articular cartilage explants in rabbit were cultured, and the degree of proteoglycan (PG) degr...

Objectives. To assess the effects of intra-articular therapy on pain sensitivity in the knee and surrounding tissues in knee OA patients. Methods. Twenty-five knee OA patients with symptomatic knee OA were included in this interventional cohort study. Pressure pain thresholds (PPT) were recorded before, immediately after, and two weeks after ultrasound guided intra-articular injection of lidoca...

This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). We also sought to determine the effect of RTX treatment on calcitonin gene-related peptide (CGRP) expression in the spinal cord. Knee join...

BACKGROUND Joint immobilisation improves the therapeutic effect of intra-articular glucocorticoid injection for knee synovitis. This may be due to retarded steroid resorption by immobilisation, a procedure that also could influence cartilage and bone metabolism. OBJECTIVE To evaluate changes in cartilage and bone turnover after intra-articular glucocorticoid treatment for knee synovitis with ...

  It has been shown that acute inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow. To investigate the role of vascular β- adrenoceptors in this event, 12 NZW rabbits were maintained anaesthetized by 1 % halothane in N2O/O2, and acute knee joint inflammation was induced by intra-articular injection of 1 ml of 2% carageenan solution 24 hours be...

Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint inflammation and cartilage degeneration. To test this hypothesis, we examined the effects of foll...