نتایج جستجو برای: artesunate

تعداد نتایج: 1720  

2011
Hong Li Chunyan Gu Yongya Ren Yang Dai Xiaojuan Zhu Jing Xu Yuhua Li Zhenning Qiu Jin Zhu Yinchang Zhu Xiaohong Guan Zhenqing Feng

Schistosomiasis is one of the most prevalent parasitic diseases in China, and hepatic fibrosis caused by schistosome infection is the principal cause of death. The aim of this study was to evaluate the efficacy of NP11-4-derived immunotoxin scFv-artesunate on Schistosoma japonicum-induced hepatic fibrosis. A single-chain variable fragment (scFv) was generated from the murine anti-Schistosoma ja...

Journal: :African health sciences 2013
Olayemi M Adegbolagun Benjamin O Emikpe Ibukun Oluwa O Woranola Yetunde Ogunremi

BACKGROUND Resistance to most antimalarial drugs has encouraged the use of herbal preparations along with prescribed orthodox drugs. OBJECTIVE this study investigated effect of co-administration of aqueous extract of T. occidentalis leaves, commonly used as antimalarial and haematinic agent in Nigeria, and artesunate using P. berghei animal model. METHODS In vivo curative antiplasmodial eff...

2016
Mohamadou Siribié IkeOluwapo O. Ajayi Jesca Nsungwa-Sabiiti Armande K. Sanou Ayodele S. Jegede Chinenye Afonne Catherine O. Falade Melba Gomes

BACKGROUND  Children aged <5 years were enrolled in a large study in 3 countries of sub-Saharan Africa because they had danger signs preventing them from being able to take oral medications. We examined compliance and factors associated with compliance with referral advice for those who were treated with rectal artesunate. METHODS  Patient demographic data, speed of accessing treatment after ...

Journal: :Antimicrobial agents and chemotherapy 2005
Steffen Borrmann Ayola A Adegnika Félicien Moussavou Sunny Oyakhirome Gilbert Esser Pierre-Blaise Matsiegui Michael Ramharter Ingrid Lundgren Maryvonne Kombila Saadou Issifou David Hutchinson Jochen Wiesner Hassan Jomaa Peter G Kremsner

Fosmidomycin is effective against malaria, but it needs to be given for > or =4 days when used alone. We conducted a study of 50 children with Plasmodium falciparum malaria to evaluate the safety and efficacy of consecutively shortened regimens of artesunate-fosmidomycin (1 to 2 mg/kg of body weight and 30 mg/kg of body weight, respectively; doses given every 12 hours). All dosing regimens were...

2015
Shan-Qing Wang Guang-Ze Wang Yu-Chun Li Feng Meng Shi-Gan Lin Zhen-Hu Zhu Ding-Wei Sun Chang-Hua He Xi-Min Hu Jian-Wei Du

Pyronaridine and artesunate have been shown to be effective in falciparum malaria treatment. However, pyronaridine is rarely used in Hainan Island clinically, and artesunate is not widely used as a therapeutic agent. Instead, conventional antimalarial drugs, chloroquine and piperaquine, are used, explaining the emergence of chloroquine-resistant Plasmodium falciparum. In this article, we invest...

2012
Chiagoziem A. Otuechere Gloria Edewor Oluwafemi Ezekiel Kale Martins Ekor

Recent instances of breakdowns of malaria control programs and the constant emergence of drug-resistant parasites to monotherapies have shored up the use of artemisinin-based combination therapy (ACT) as the malaria therapy of choice. We evaluated a subacute therapeutic dosing of artemether-lumefantrine and artesunate-amodiaquine on plasma cholesterol, renal antioxidants, and organ weights in r...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2003
Mai Huong Nguyen Timothy M E Davis Janet Cox-Singh Sean Hewitt Quoc Toan Tran Bach Kim Tran Thi Hanh Nguyen Nhu Phuong Vo Hanh Nhan Doan Dinh Cong Le

The effectiveness of chloroquine or sulfadoxine-pyrimethamine administered with artesunate for treating uncomplicated falciparum malaria was assessed in 2 Vietnamese provinces where the sensitivity of parasites in vitro to conventional therapies had increased with the removal of drug pressure. In the province of Dac Lac, where potential malaria exposure begins at birth, 57 subjects (mean age, 9...

Journal: :American journal of therapeutics 2011
Akintunde Sowunmi Grace Olusola Gbotosho Christian Tientcha Happi Onikepe Folarin Titilope Okuboyejo Obaro Michael Bayo Fatunmbi

To evaluate the effects of antimalarial drugs on Plasmodium falciparum malaria-associated anemia, we use the area under the curve (AUC) of anemia levels after treatment as an approach to combine their duration and magnitude. The method involves numeric estimation, by trapezoidal rule, of AUC from a plot of deficit in hematocrit levels from 30% (the lower threshold of normal) versus time in anem...

Journal: :The Southeast Asian journal of tropical medicine and public health 2008
Noppadon Tangpukdee Srivicha Krudsood Vipa Thanachartwet Chaweewan Pengruksa Nanthaporn Phophak Shigeyuki Kano Guoqiao Li Gary M Brittenham Sornchai Looareesuwan Polrat Wilairatana

To determine the efficacy, safety and tolerability of an alternative short-course, artemisinin-based combination therapy for acute uncomplicated Plasmodium falciparum malaria, we compared Artequick--a fixed-dosed combination of artemisinin (80 mg), piperaquine (400 mg), and primaquine (4 mg), per tablet--with a standard regimen of artesunate-mefloquine. A total of 130 patients were randomly ass...

2016
Marian Warsame Margaret Gyapong Betty Mpeka Amabelia Rodrigues Jan Singlovic Abdel Babiker Edison Mworozi Irene Agyepong Evelyn Ansah Robert Azairwe Sidu Biai Fred Binka Peter Folb John Gyapong Omari Kimbute Zena Machinda Andrew Kitua Tom Lutalo Melkzedik Majaha Jao Mamadu Zakayo Mrango Max Petzold Joseph Rujumba Isabela Ribeiro Melba Gomes

BACKGROUND  If malaria patients who cannot be treated orally are several hours from facilities for injections, rectal artesunate prior to hospital referral can prevent death and disability. The goal is to reduce death from malaria by having rectal artesunate treatment available and used. How best to do this remains unknown. METHODS  Villages remote from a health facility were randomized to di...

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