Venous thromboembolism (VTE) is a leading cause of cardiovascular death. Omega-3 fatty acids (n-3 FA) exhibit protective effects against cardiovascular disease. Others and our group have reported that the plant-derived n-3 FA alpha-linolenic acid (ALA) displays antiinflammatory, anticoagulant and antiplatelet effects, thereby reducing atherosclerosis and arterial thrombosis in mice fed a high A...

Atherosclerotic stenosis of the major intracranial arteries (intracranial internal carotid artery, middle cerebral artery, vertebral artery, basilar artery) is probably the most common cause of stroke worldwide.1 Intracranial atherosclerosis causes 30% to 50% of strokes in Asia2 and 8% to 10% of strokes in North America.3 This review focuses on the medical and endovascular treatment of atherosc...

Eighty-one young Japanese patients with occlusive thromboaortopathy (Takayasu's disease) were classed into three groups according to the degree and extent of diameter stenosis in the 4 cervical arterial systems, as determined by serial aortography. Class I was made up of 63 patients with 70% or greater stenosis in less than 3 systems, including 33 patients without systemic hypertension (Class I...

Randomized controlled trials have not shown that surveillance of graft blood flow (Q) prolongs graft life. Because luminal diameters affect flow resistance, this study examined whether the influence of diameters on Q can explain the limitations of surveillance. Inflow artery and outflow vein diameters were determined from duplex ultrasound studies of 94 patients. These diameters were applied to...

The arterial switch operation (Jatene procedure) is the treatment of choice for transposition of the great arteries with intact ventricular septum (TGA-IVS) in neonatal age, because of the low mortality and morbidity during long term follow up. Right ventricular outflow obstruction is the most frequent postoperative complication, occurring with suYcient severity to require reintervention in up ...

"Degenerative" or calcific aortic stenosis is a complex, multifaceted, systemic disease that is not solely limited to the aortic valve but also includes reduced arterial compliance as well as alterations of left ventricular geometry and function. This particular nature of the disease underscores the need for a more comprehensive evaluation of disease severity going beyond the standard parameter...

BACKGROUND fluid dynamic analysis predicts a new concept in coronary physiology that we call "branch steal," whereby stenosis proximal and distal to arterial branching interact with the nonstenotic branch between stenosis that shunts or "steals" flow away from the distal stenotic artery during reactive hyperemia, tested experimentally. METHODS AND RESULTS in 21 large hounds under surgical ane...