We read the original article by Nuis, et al. [1] and the reply by Dogan, et al. [2] with great interest. Nuis, et al. [1] examined whether transcatheter aortic valve implantation (TAVI) in patients suffering from severe aortic stenosis led to changes in corrected QT dispersion (cQTD), previously used to predict arrhythmic risk. Dogan, et al. [2] proposed that a different marker, transmural disp...

QT dispersion (QTD) on 12-lead ECGs has been proposed as a marker of malignant ventricular tachyarrhythmias, and increased QTD has been reported in long QT syndrome (LQTS). On the other hand, it has been demonstrated that transmural dispersion is associated with ventricular tachyarrhythmias in an experimental model. However, the precise type of QTD or transmural dispersion that contributes most...

Sex is a major determinant of the incidence and clinical presentation in arrhythmia syndromes such as Brugada syndrome (BrS). We generated novel SCN5A-G1408R/+ knock-in mouse model mimicking key features human BrS regarding male predominance susceptibility to ventricular tachycardias. This study aimed explore effect molecular mechanisms androgen deprivation on cardiac arrhythmogenicity BrS. Ani...

BACKGROUND: Propofol administration in patients with Brugada syndrome (BrS) is still a matter of debate. Despite lacking evidence for its feared arrhythmogenicity, up to date, expert cardiologists recommend avoiding propofol. The main aim this study assess the occurrence malignant arrhythmias or defibrillations BrS, during and 30 days after propofol administration. secondary investigate adverse...

The cardiac effects of hypothermia have been studied for many years since the initial discovery electrocardiographic J-wave in a case accidental hypothermia. However, precise mechanisms underlying origin hypothermic and associated arrhythmias man are still debated. A limited number ex vivo animal studies focused on transmural repolarization dispersion, but do not provide global mapping ventricu...

BACKGROUND Hypertrophic cardiomyopathy (HCM), the most common mendelian heart disorder, remains an orphan of disease-specific pharmacological treatment because of the limited understanding of cellular mechanisms underlying arrhythmogenicity and diastolic dysfunction. METHODS AND RESULTS We assessed the electromechanical profile of cardiomyocytes from 26 HCM patients undergoing myectomy compar...

OBJECTIVE Left ventricular hypertrophy has been associated with the prolongation of QT-time, and an increased risk of ventricular arrhythmias. The renin angiotensin system has been implicated in the development of ventricular hypertrophy. At 5 weeks complete AV block (CAVB) in the dog, there is: (1) biventricular hypertrophy associated with a transient activation of components of the renin angi...

AIMS Human ether-à-go-go-related gene (hERG) missense mutations N588K and L532P are both associated with atrial fibrillation (AF). However, the underlying gain-of-function mechanism is different. The aim of this computational study is to assess and understand the arrhythmogenic mechanisms of these genetic disorders on the cellular and tissue level as a basis for the improvement of therapeutic s...

OBJECTIVE We reported that experimental autoimmune myocarditis (EAM) rats showed dramatic changes in ventricular action potential and enhanced arrhythmogenicity in the acute phase, but mechanisms for this are still unclear. To investigate the mechanisms of cardiac remodeling in acute myocarditis and subsequent heart failure, physiological and molecular changes were evaluated along the time cour...

This study tested the hypothesis that concomitant sympathetic and parasympathetic stimulation ("autonomic conflict") may act as a trigger for arrhythmias in long QT syndrome (LQTS). Studies were performed in isolated innervated rabbit hearts treated with clofilium (100 nmol/L); a potassium channel blocker. The influence of vagus nerve stimulation (VNS) on spontaneous ventricular arrhythmias was...