ONE of the main steps in the elucidation of the mechanism of ovum implanta-tion is to determine how the blastocyst stimulates the uterus to undergo a decidual reaction. The extent of this reaction varies between species but is particularly marked in rodents, and normal ovum implantation does not occur without it. It has been known for several years, however, that the uterus of a suitably primed...

The uterus and placenta of the mouse and rat produce a member of the prolactin (PRL) family referred to as decidual/trophoblast PRL-related protein (d/tPRP). This cytokine/hormone has been hypothesized to regulate decidual cell activities needed for the establishment and maintenance of gestation. An alkaline phosphatase (AP)-tagging strategy was used to identify d/tPRP target cells. AP-d/tPRP b...

The objective was to verify the hypothesis of a 'first uterine pass effect' or direct preferential vagina-to-uterus transport, suggested by the evidence of higher than expected uterine tissue concentrations after vaginal administration of progesterone; we used a human ex-vivo uterine perfusion model. A mixture of tritiated (3H) and unlabelled progesterone was applied to the cuff of vaginal tiss...

Although the morphological and physiological changes involved in pregnancy in live-bearing reptiles are well studied, the genetic mechanisms that underlie these changes are not known. We used the viviparous African Ocellated Skink, Chalcides ocellatus, as a model to identify a near complete gene expression profile associated with pregnancy using RNA-Seq analyses of uterine transcriptomes. Pregn...

UNLABELLED A reported increase in the incidence of infertility following high genistein intake could be related to alteration in the normal fluid volume and morphology of the uterus in adult female. In view of this, we investigated the effect of this compound on fluid secretion, fluid volume and morphology of the uterus in post-pubertal rats. METHODS Ovariectomised SD rats were treated with 1...

BACKGROUND Making a histologic diagnosis of leiomyosarcoma in the specimen from a hysterectomy performed for suspected benign fibroids is rare. Currently, there are no reliable diagnostic tools to diagnose uterine sarcomas preoperatively. CASE A 38-year-old woman presented with menorrhagia and a uterine fibroid measuring 6.0 cm x 8.1 cm x 6.2 cm on ultrasonography. The patient underwent a lap...

Didelphys uterus, or double uterus, is an embryological developmental malformation of the müllerian ducts with the incidence of approximately 8.3% of all müllerian duct abnormalities (MDAs). Didelphys uterus accompanying dicavitary twin gestation is encountered as a very rare entity with overall incidence of about 1 in 1,000,000. We report a rare case of didelphys uterus, diagnosed since her fi...

this study explored the effects of gnrh agonist (gnrha) immunity on expression of fshr mrna in pituitary and fshr protein in uteri, and also confirmed its efficacy on uterine development. 42 prepuberty and non cyclic ewes were assigned to 6 experimental groups (eg) during anestrus season. animals in eg-i, eg-ii and eg-iii were subcutaneously injected with 200, 300 and 400 μg alarelin antigens (...

According to the literature the prevalence of congenital uterine anomalies varies between 3.4 and 5.0% and Müllerian anomalies are found more often in subfertile patients compared to fertile controls (Raga et al., 1997; Grimbizis et al., 2001). Congenital malformations of the Müllerian system are probably caused by multifactorial polygenic and familial factors. The prevalence of a unicornuate u...

Brachytherapy is an integrating component for the treatment of locally advanced cervical cancer. While most women present anteverted or intermediary position uterus, only 20–25% have retroverted uterus. We evaluated 418 high-dose-rate brachytherapy plans of patients diagnosed with biopsy proven cervical cancer. Urinary bladder and rectal points were identified on the orthogonal digital X-ray im...