In this study we demonstrated that two polyunsaturated fatty acids, arachidonic acid (AA, n-6) and docosahexaenoic acid (DHA, n-3), modulate the secretion of bile salt-dependent lipase (BSDL) by pancreatic AR4-2J cells. The effects of AA and DHA were also compared with that of the monounsaturated fatty acid, oleic acid (OA). Our results showed that the chronic treatment of cells with AA or DHA,...

[1] The responses of tropical cyclone (TC) potential intensity (PI) and the associated environmental control parameters over the North Indian Ocean (NIO) to the doubled CO2 concentration are assessed based on the ensemble simulation from 15 coupled general circulation models (CGCMs) participated in the Intergovernmental Panel for Climate Change (IPCC) Forth Assessment Report (AR4). The results ...

Physically based projections of the Greenland ice sheet contribution to future sea-level change are subject to uncertainties of the atmospheric and oceanic climatic forcing and to the formulations within the ice flow model itself. Here a higher-order, three-dimensional thermomechanical ice flow model is used, initialized to the present-day geometry. The forcing comes from a high-resolution regi...

Climate models predict a gradual weakening of the North Atlantic meridional overturning circulation (MOC) during the twenty-first century due to increasing levels of greenhouse gas concentrations in the atmosphere. Using an ensemble of 16 different coupled climate models performed for the Fourth Assessment Report (AR4) of the Intergovernmental Panel on Climate Change (IPCC), the evolution of th...

Recent simulations predicted that the stratospheric ozone layer will likely return to pre-1980 levels in the middle of the 21st century, as a result of the decline of ozone depleting substances under the Montreal Protocol. Since the ozone layer is an important component in determining stratospheric and tropospheric-surface energy balance, the recovery of stratospheric ozone may have significant...

In previous studies on the AR4-2J cell line, we have shown that secretion of bile salt-dependent lipase (BSDL) involves a multiprotein complex, including a protein of 94 kDa (p94) that is immunologically related to the chaperone Grp94, which seems to play essential roles in the folding process of BSDL. Combined biochemical and immunocytochemical investigations were carried out to study the secr...