Abstract Noble gases in lunar soils provide critical information regarding solar wind and cosmic-ray interactions with the surface, as well history of impact events affecting regolith turnover processes. Here, we studied characteristics noble He, Ne, Ar Chang’E-5 soil. High 4 He/ 36 20 Ne/ values show that soil has typical mare terrain characteristics. Furthermore, both are higher than those ot...

Augmented Reality (AR) annotations are a powerful way of communication when collaborators cannot be present at the same time in given environment. However, this situation presents several challenges, for example: how to record AR later consumption, align virtual and real world unprepared environments or offer users with different devices. In paper we cross-device annotation method that allows c...

The time-dependent kinetics of formation and evolution nanosize atomic clusters is investigated illustrated with the nucleation dynamics ion-seed ${\mathrm{Ar}}_{n}{\mathrm{H}}^{+}$ particles. rates growth degradation Ar-atomic shells around seed ion are inferred from molecular (MD) simulations. Simulations cluster have been performed accurate quantum-mechanical binary interaction potentials. B...

OBJECTIVE To examine the results of root replacement with aortic valve-sparing in patients with bicuspid aortic valve (BAV) or severe aortic regurgitation (AR). METHODS Between 2000 and 2009, 102 patients (mean age 47±17.5 years) underwent aortic valve-sparing procedures for ascending aortic aneurysm or dissection. Patients were assigned to three different groups according to the aortic valve...

Differences in the degree of trapping of initial block by N-methyl-D-aspartate (NMDA) receptor antagonists may affect their safety and, hence, suitability for clinical trials. In this comparative study, 23 compounds structurally related to the low-affinity, use-dependent NMDA receptor antagonist (S)-alpha-phenyl-2-pyridineethanamine dihydrochloride (AR-R15896AR) were examined to determine the d...

Ligand-dependent activity of steroid receptors is affected by tetratricopeptide repeat (TPR)-containing co-chaperones, such as small glutamine-rich tetratricopeptide repeat-containing alpha (SGTA). However, the precise mechanisms by which the predominantly cytoplasmic TPR proteins affect downstream transcriptional outcomes of steroid signaling remain unclear. In this study, we assessed how SGTA...

The sorbitol pathway in human lenses is evaluated on the enzymic level. Adult lenses, normal and nondiabetic as well as diabetic cataracts, are found to contain limited levels of aldose reductase (AR) and high levels of polyol dehydrogenase (PD) relative to the animal lens. AR is confined primarily to the lens epithelium and is two to three times higher in juvenile lenses than in the adult lens...

We investigated whether activation of A(1) or A(3) adenosine receptors (ARs) induces late preconditioning (PC) against infarction in conscious rabbits using the selective AR agonists 2-chloro-N(6)-cyclopentyladenosine (CCPA) and N(6)-3-iodobenzyladenosine-5'-N-methylcarboxamide (IB-MECA). In vitro radioligand binding and cAMP assays demonstrated CCPA to be approximately 200- to 400-fold selecti...

Mass extinctions manifest in Earth's geologic record were turning points in biotic evolution. We present (40)Ar/(39)Ar data that establish synchrony between the Cretaceous-Paleogene boundary and associated mass extinctions with the Chicxulub bolide impact to within 32,000 years. Perturbation of the atmospheric carbon cycle at the boundary likely lasted less than 5000 years, exhibiting a recover...