We previously developed a new formulation of methotrexate (MTX) that is adsorbed onto a suspension of activated carbon particles (MTX-CH) and reported the usefulness of local administration in murine tumors. The present study examines the effects of human colon carcinoma (LoVo) xenografts and the acute toxicity of MTX-CH compared with MTX aqueous solution (MTX-AQ) in mice. In therapeutic experi...

Crystal structure prediction studies indicated the existence of an unknown high density monohydrate structure (Hy1B°) as global energy minimum for 4-aminoquinaldine (4-AQ). We thus performed an interdisciplinary experimental and computational study elucidating the crystal structures, solid form inter-relationships, kinetic and thermodynamic stabilities of the stable anhydrate (AH I°), the kinet...

Carbon physiology of a genetically identified Ulva rigida was investigated under different CO2(aq) and light levels. The study was designed to answer whether (1) light or exogenous inorganic carbon (Ci) pool is driving growth; and (2) elevated CO2(aq) concentration under ocean acidification (OA) will downregulate CAext-mediated [Formula: see text] dehydration and alter the stable carbon isotope...

The rapid development of falciparum resistance to sulphadoxine-pyrimethamine (SP) in East and Central Africa has raised concerns as to the efficacy of combining it with another drug. In 2002, we assessed the efficacy of SP alone and combined with amodiaquine (AQ/SP) or chloroquine (CQ/SP) in Ugandan children with uncomplicated falciparum malaria. At day 14, adequate clinical response was 100% (...

We evaluated the effect of several compounds on their ability to reduce the production of sul®de in in vitro ruminal fermentations, when sulfur content of the diet was 1% (dry matter basis). Excess sulfur increased (p<0.05) ruminal sul®de production, but had no effects on VFA production. The effect of 1, 10 and 25 ppm ( ̄uid basis) of 9,10 anthraquinone (AQ) and molybdenum in high sulfur diets w...

Approximate nearest neighbor (ANN) search is fundamental for fast content-based image retrieval. While vector quantization one key to performing an effective ANN search, in order further improve accuracy, we propose enhanced accumulative (E-AQ). Based on our former work, introduced the idea of quarter point into (AQ). Instead finding centroid, was used quantize and computed each according its c...

A dynamical algebra Aq, englobing many of the deformed harmonic oscillator algebras is introduced. One of its special cases is extensively developed. A general method for constructing coherent states related to any algebra of the type Aq is discussed. The construction following this method is carried out for the special case.

Egelstaff–Widom correlation length, 198 ensemble dependence of PDT, 43 entropy convergence of hydrophobicities, 187 entropy from the trajectory, 103 equilibrium ratios ideal, 24 non-ideal, 146 Ewald lattice sums, 112 Ewald potential, 108 examples bacterial Cl− channel structure, 15 Be2+(aq), 149 ion channels, 13 K+(aq), 157 Nafion®, 9 reversed phase liquid chromatography (RPLC), 5 triflic acid,...