BACKGROUND Traumatic hemothorax (HTX) has been demonstrated to predictably contain low fibrinogen, low hematocrit, and low platelet counts. When analyzed on its own, shed HTX demonstrates coagulopathy. However, when mixed with normal pooled plasma (NPP) at physiologically relevant dilutions, HTX demonstrates accelerated coagulation. We hypothesize that when HTX is mixed with a patient's own pla...

Autoimmune phenomena, most frequently autoimmune hemolytic anemia, is a well-known complication of lymphoproliferative diseases. We report a very rare association of a chronic lymphocytic leukemia with an acquired factor XI inhibitor. A 87-year-old man presented with auto-immune hemolytic anemia. He had untreated chronic lymphocytic leukemia for the past three years and renal insufficiency. Bef...

Renal graft thrombosis is a rare but devastating complication of renal transplantation. It accounts for one-third to one-half of early graft losses. We report a patient with acute renal artery and vein thrombosis associated with abnormally short activated partial thromboplastin time (aPTT) and factor V Leiden mutation. Vascular thrombosis developed on the ninth post-transplant day and led to a ...

The anticoagulant effect of Dabigatran etexilate, Rivaroxaban, and Apixaban is dose-predictable, steady, and little influenced by diet and drugs [1]. Thus, similar to lowmolecular weight heparin, laboratory tests have been unnecessary to evaluate such direct oral anticoagulant drugs (DOACs) in trials on thromboprophylaxis (Table 1). Nor such testing was needed in patients with atrial fibrillati...

Haemost 2013; 110: 308-315. Dabigatran, an oral thrombin inhibitor, is licensed as an alternative to warfarin for stroke prevention in patients with atrial fibrillation. As the first of the new oral anticoagulants (NOACs) to gain approval for this indication, its use is increasing now that its safety has been confirmed using real-world data (1, 2), and clinical guidelines have given preference ...

We report on a 57-year-old woman with a pontine haemorrhage and an extremely prolonged activated partial thromboplastin time (aPTT) of more than 240 s, suggestive of a coagulation disorder. Given the location of the haemorrhage, which is associated with a high mortality rate, recombinant factor VIIa was administered, although not all necessary laboratory analyses could be performed at that time...

An 85-year-old woman underwent emergent splenectomy due to left abdominal pain and active bleeding in a massively enlarged spleen. The histological diagnosis was splenic marginal zone lymphoma (SMZL). A prolonged activated partial thromboplastin time (APTT) was noted, and additional tests led to the diagnosis of type 2A-like acquired von Willebrand syndrome (AVWS). An APTT cross mixing test rul...

A 24-year-old healthy multigravid patient developed postpartum hemorrhage 3 days post normal delivery. She underwent curettage × 3 followed by laparotomy and hysterectomy. Postoperatively she developed a subrectus hematoma that required laparotomy and drainage. Persistent bleeding per vaginum prompted a third laparotomy for internal iliac ligation, which could not be carried out due to massive ...

Mục tiêu: Mô tả đặc điểm lâm sàng, xét nghiệm rối loạn đông máu ở trẻ sơ sinh nhiễm khuẩn huyết tại Trung tâm Nhi khoa, Bệnh viện ương Thái Nguyên. Phương pháp nghiên cứu: cứu mô tiến 38 bệnh nhân khoa. Kết quả: triệu chứng của hay gặp là khó thở 86,8%, bú kém 84,2%, có 34,2% biểu hiện xuất dưới da, chảy phổi 10,6%. Số lượng tiểu cầu giảm chiếm 55,3% trường hợp; tỉ lệ prothrombin 44,7%, thời gi...