Noscapine is a natural alkaloid with anti-angiogenesis activities. The aim of the present study was to examine the effect of noscapine on eutopic endometrium of endometriosis patients (EEE) and normal endometrium (NE)in a three-dimensional (3D) culture model. In this experimental in-vitro study, EEE (n = 8) and NE (n = 8) biopsies were taken from 16 reproductive aged women. The biopsie...

OBJECTIVE To identify novel gene expression networks in blood of osteoarthritis patients compared to controls. METHODS A comprehensive exploration of gene expression in peripheral blood was performed by microarray analysis for a subset of osteoarthritis patients from the Genetics osteoARthritis and Progression (GARP) study in comparison with sex and age-matched healthy controls. To identify p...

Androgen receptor (AR) signaling is crucial to the development and homeostasis of the prostate gland, and its dysregulation mediates common prostate pathologies. The mechanisms whereby AR regulates growth suppression and differentiation of luminal epithelial cells in the prostate gland and proliferation of malignant versions of these cells have been investigated in human and rodent adult prosta...

Diabetes and its complications, such as delayed wound healing, are increasing at an alarming rate in India, putting enormous strain on the country’s limited healthcare resources. Hence, present study proposes to screen/identify possible mechanisms effect of flavonoid-enriched fraction Selaginella bryopteris extract against human keratinocyte cell lines (HaCaT) streptozocin (STZ)-induced diabeti...

This survey was performed to aim of synthesize Nano emulsion from Ferula gummosa essential oil (FEGO-NE) and evaluate its anti-tumor effect. First, analyzed by GC–MS method, then the synthesized as O/W after characterization DLS, Zeta potential, AFM, FESEM TEM methods, toxicity evaluated MTT method. Then pro-apoptotic effects were qPCR (Caspase3, 9, Bax Bcl-2) method AO/PI staining. The cancer ...

Clearance of apoptotic cells by macrophages occurs as a coordinated process to ensure tissue homeostasis. Macrophages play a dual role in this process; first, a rapid and efficient phagocytosis of the dying cells is needed to eliminate uncleared corpses that can promote inflammation. Second, after engulfment, macrophages exhibit an anti-inflammatory phenotype, to avoid unwanted immune reactions...

INTRODUCTION Sepsis is associated with a dysregulation of apoptosis in immune cells, which has been implicated in both immunosuppression and multiple organ failure. We describe the expression profiles of genes encoding key regulators of apoptosis in highly purified monocytes, granulocytes and CD4+ T lymphocytes. METHODS Sixteen patients with sepsis were recruited from the intensive care unit ...