Activation and repression of transcription are primarily caused by gene regulatory proteins (activators and repressors), which act by binding to specific sites on DNA. The steps from initial binding of RNA polymerase to the elongating complex are characterized by many intermediates, each with a discrete structure, offering many mechanistic possibilities for regulator actions. It has been shown ...

There are only very few natural ways in which arbitrary functions can be combined. One composition operator is override: for arbitrary functions f and g, f > g is the function with domain dom( f) U dom(g) that behaves like f on dom( f) and like g on dom(g) \ dom( f ) . Another operator is update: f[g] has the same domain as f, behaves like f on dom( f) \ dom(g), and like g on dom( f) n dom(g). ...

Genetic analysis shows that Engrailed (En), a homeodomain-containing transcription factor, has both negative and positive targets. Negative regulation is expected from a factor that has a well-defined repressor domain but activation is harder to comprehend. We used VP16En, a form of En that had its repressor domain replaced by the activation domain of VP16, to show that En activates targets usi...

The Ssn6/Tup1 general repression complex represses transcription of a number of regulons through recruitment by regulon-specific DNA-binding repressors. Rox1 and Mot3 are Ssn6/Tup1-recruiting, DNA-binding proteins that repress the hypoxic genes, and Rfx1 is a Ssn6/Tup1-recruiting, a DNA-binding protein that represses the DNA damage-inducible genes. We previously reported that Rox1 and Mot3 func...

This study investigates the role of neutrophils in ischemia-induced aspermatogenesis in the mouse. Previous studies in the rat have demonstrated that ischemia-inducing testicular torsion followed by torsion repair and reperfusion resulted in germ cell-specific apoptosis. This was correlated with an increase in neutrophil adhesion to subtunical venules, an increase in reactive oxygen species, an...

(1) For all real numbers a, b such that max(a,b)≤ a holds max(a,b) = a. (2) For all real numbers a, b, c, d holds max(a+ c,b+d)≤ max(a,b)+max(c,d). (3) For all real numbers a, b, c, d, e, f such that a ≤ b + c and d ≤ e + f holds max(a,d) ≤ max(b,e)+max(c, f ). (4) For all finite sequences f , g holds domg ⊆ dom( f a g). (5) For all finite sequences f , g such that len f < i and i≤ len f + leng...

Providing efficient access to XML documents is crucial, as XML has become the most important technique to exchange data in WWW. DOM is a popular object-oriented user interface to manipulate XML documents. Several concurrency control protocols have been proposed for DOM by analyzing the read/write behaviors of DOM operations. However, none of them exploit the semantics of DOM operations for enha...

The aims of our study were to compare the dominant (DOM) and non-dominant (NDOM) shoulders of high-level volleyball athletes and identify possible associations of shoulder adaptations with spike speed (SS) and shoulder pathology. A total of 22 male volleyball players from two teams participating in the first division of the Cypriot championship underwent clinical shoulder tests and simple measu...

Analizom demografske slike Republike Hrvatske vidljivo je kako postotak ljudi treće životne dobi bilježi rast već dulji niz godina. Iz tog razloga teži se unaprjeđenju kvalitete života i stvaranju primjerenih uvjeta za cjeloživotno obrazovanje starije populacije općenito, a samim time boravak u domovima nemoćne. Domska pedagogija temelji na proučavanju domovima, što predmet ovoga rada. Dom kao ...