today’s knowledge on oesophageal adenocarcinoma and its rising incidence has encouraged researcher to illustrate relationship between barrett’s disease and progression to adenocarcinoma. the incidence of this disease has been accelerated sharply in current decades since people life has changed. studies have been demonstrated that several potential factors including genetical  and environmental ...

background: one of the most common cancers is skin cancer worldwide. since incidence and cost of treatment of the cancer are increasing, it is necessary to further investigate to prevent and control this disease. this study aimed to determine skin cancer trend and epidemiology in iran. methods: this study was done based on existing data. data used in this study were obtained from a national reg...

background listeria monocytogenes has been isolated from various foods and environments in temperate areas, tropical countries and different parts of iran. the bacterium as a psychrotrophic organism is capable of growth at refrigeration temperatures. objective the current study was conducted to determine the incidence of listeria spp. on the surfaces of domestic refrigerators in ahvaz city as a...

background: in iran, methadone has been used for methadone maintenance treatment (mmt) as well as analgesic treatment in pain clinics. recently, there are some reports regarding accidental and intentional methadone poisonings and deaths. the aim of this study was to evaluate the trend of methadone poisonings and deaths during a 10-year period in tehran, iran. methods: this was a retrospective c...

background: animal bite is an important and preventable health hazard. this study aimed to determine the epidemiology of animal bites in north khorasan province in iran.   materials and methods: data gathered from health centers from march 2005 until december 2011 were used for this cross-sectional descriptive study of animal bites.   results: a total of 18,517 animal bite cases were reported d...

A considerable amount of evidence indicates that Ras signaling contributes to the development of endometrial cancer. We previously demonstrated that endometrial cancer cells carrying oncogenic [Val]K-ras were susceptible to apoptosis. The present study examined the role of K-and H-Ras in the induction of apoptosis using rat endometrial cells (RENT4 cells). We found that constitutively activated...

Apoptosis plays a key role in the maintenance of a constant cell number and a low incidence of cancer in the mucosa of the intestine. Although the small GTPase Rac1 has been established as an important regulator of migration of intestinal epithelial cells, whether Rac1 is also involved in apoptosis is unclear. The present study tested the hypothesis that Rac1 mediates TNF-alpha-induced apoptosi...

Ovarian cancer is one of the most common types of gynecologic malignant tumor, with high incidence and high mortality rates. It is difficult to diagnose ovarian cancer early due to the complex structure and function of the ovaries. Siva 1 is a well-known pro-apoptosis protein that functions in multiple types of cancer cells: There are several studies demonstrating that Siva 1 arrests apoptosis ...

background apoptosis is a physiological mechanism of cell death and it can be triggered by a variety of internal and external stimuli. it has been indicated that some opium derivatives develop cell apoptosis. objectives the aim of this investigation was to evaluate the effect of opium addiction on ovary cell apoptosis in diabetic and non-diabetic wistar rats. materials and methods this experime...

Introduction: To increase therapeutic ratio, using radio-sensitizers is recommended and nowadays some types of them are utilized clinically. In recent years, Gold nanoparticles (GNPs) were considered as radio-sensitizers in many studies due to high atomic number. Although theoretical works showed that GNPs have an insignificant effect at MV energies, some In-vitro and In-vivo s...