Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid, and neurofibrillary tangles of Alzheimer disease. In vitro, apolipoprotein E in cerebrospinal fluid binds to synthetic beta A4 peptide (the primary constituent of the senile plaque) with high avidity. Amino acids 12-28 of the beta A4 peptide are required. The gene for apolipoprotein E is located on chromosom...

The apolipoprotein E-ε4 allele is a well-known genetic risk factor for late-onset Alzheimer's disease, which also impacts the cognitive functions and brain network connectivity in healthy middle-aged adults without dementia. Previous studies mainly focused on the effects of apolipoprotein E-ε4 allele on single index using task or resting-state fMRI. However, how these evoked and spontaneous BOL...

BACKGROUND Intravenous and inhalation anesthesia are commonly used in the clinical setting. Recovery of cognitive function in elderly patients after surgery has received increased attention. In this study, the authors compared recovery of cognitive function in patients after different anesthesia techniques, and investigated which technique is safer. The authors also explored association between...

Lipoprotein(a) levels in plasma are considered an independent risk factor for atherosclerosis at different sites. Although Lp(a) measurements have recently gained interest in clinical laboratories, several problems are still unresolved. A potential source of pre-analytical variability lies in the treatment of the specimens, since it has been reported that values of several lipid quantities are ...

The 14 allele of the apolipoprotein E gene constitutes the major genetic risk factor to develop Alzheimer’s disease. If and how this protein contributes to the pathological cascade of Alzheimer’s disease is not known. The 14 allele particularly affects the cholinergic defect, which is one of the most consistent neurotransmitter problems in an Alzheimer’s disease brain. We have analysed several ...

This review assesses current knowledge of the clinical, genetic, and biochemical features of familial high density lipoprotein (HDL) deficiency syndromes. The focus is on HDL deficiency states occurring in the absence of severe hypertriglyceridemia or lecithin/cholesterol acyltransferase deficiency. Specific entities falling within this category include Tangier disease, familial HDL deficiency ...

This study was conducted to investigate the effects of dietary curcumin on hepatic lipid metabolism and antioxidant capacity in Roman laying hens. A total 144 hens (28 weeks old) were allocated 4 treatments that included at concentrations 0, 50, 150, 250 mg/kg for 9 weeks. Each treatment had 6 replicates per group with replicate (2 birds/cage). The results showed supplementation decreased (P < ...