although the majority of the cornea was nonedematous, there was marked corneal edema in the area of the GV markings with bulla noted (Figure 1). Over several weeks, the edema gradually resolved with interface haze in the area of prior edema. The visual acuity resolved to 20/40 without correction. Case 2. A 67-year-old woman with a history of Fuchs endothelial dystrophy presented with gradual on...

Acute keratoconus is the term applied to the sudden development of a gross degree of corneal oedema in a patient with a pre-existing keratoconus. This rare condition was probably first described by Terrien (I906). An association between mongolism and acute keratoconus has recently been observed, the first two cases having been reported by Hoffmann (I956). Three cases (two bilateral) are reporte...

PURPOSE Retropupillary fixation of an iris-claw intraocular lens (IOL) (Verisyse, Abbott Medical Optics) was performed for aphakic eyes without sufficient capsular support, and safety and recovery of the procedure were compared with transscleral suturing fixation. METHODS This interventional case series comprised 11 eyes of 10 aphakic patients without capsular support undergoing retropupillar...

This study comprises 12 corneal buttons removed at the time of keratoplasty from patients with bullous keratopathy due to Fuchs' dystrophy. All except one were aphakic. Three had vitreous contact to the endothelium. One patient had several intraocular procedures. Specimens were processed for scanning electron microscopy and dried in a freeze-drying or critical-point machine. Portions of these s...

Corneal endothelial cells play a critical role in maintaining corneal transparency and dysfunction of these cells caused by aging, diseases (such as Fuch's dystrophy), injury or surgical trauma, which can lead to corneal edema and blindness. Due to their limited proliferative capacity in vivo, the only treatment method is via transplantation of a cadaver donor cornea. However, there is a severe...

Spectacle correction for eyes with refractive errors is still the most widely used method, but very high-powered spectacle lenses, besides their unpleasing appearance, have the inherent drawbacks of spherical and chromatic aberrations, prismatic effects, and limitation of the visual fields. Contact lenses present their own problems in the form of intolerance, allergy, irritation, and conjunctiv...

Proper corneal hydration is maintained by a Na, K-ATPase pump located in the lateral membranes of the endothelial cells. In dysfunctional corneas this pumping action appears to break down as the corneas become edematous. In order to provide quantitative and qualitative data on the Na, K-ATPase pump site density on dysfunctional and functional human corneal endothelial cells, the present study h...

PURPOSE To evaluate and compare the toxic effects of eyedrops containing a fixed combination of 2.0% dorzolamide and 0.5% maleate timolol with or without preservatives on rabbit corneal endothelium. METHODS This study was performed with 22 eyes of New Zealand white rabbits. Dorzolamide/timolol eyedrops with preservative (Cosopt group) or without preservative (Cosopt-S group) were diluted with...

PURPOSE To investigate the time course of corneal thickness changes in overnight hyperopic orthokeratology (OK) lens wear for a 4-day lens-wearing period. METHODS Fourteen subjects (age range, 20-37 years) were fitted with hyperopic OK lenses in one eye only. The fellow eye acted as a non-lens wearing control. Lenses were worn overnight only for 4 nights, and changes from baseline in subjecti...

PURPOSE Lenticule implantation can be used to correct vision problems. However, it is significantly restrained by the sources of autologous lenticules. The aim of the present study was to investigate the feasibility and effects of femtosecond laser-assisted corneal small incision allogenic intrastromal lenticule implantation (AILI) in monkeys. METHODS Six healthy adult monkeys were included i...