نتایج جستجو برای: apaf1

تعداد نتایج: 548  

Journal: :Blood 2014
Elise Peterson Lu Michael McLellan Li Ding Robert Fulton Elaine R Mardis Richard K Wilson Christopher A Miller Peter Westervelt John F DiPersio Daniel C Link Matthew J Walter Timothy J Ley Timothy A Graubert

Apoptosis and the DNA damage responses have been implicated in hematopoietic development and differentiation, as well as in the pathogenesis of myelodysplastic syndromes (MDS) and leukemia. However, the importance of late-stage mediators of apoptosis in hematopoiesis and leukemogenesis has not been elucidated. Here, we examine the role of caspase-9 (Casp9), the initiator caspase of the intrinsi...

2013
Laura Lupini Cristian Bassi Manuela Ferracin Nenad Bartonicek Lucilla D'Abundo Barbara Zagatti Elisa Callegari Gentian Musa Farzaneh Moshiri Laura Gramantieri Fernando J. Corrales Anton J. Enright Silvia Sabbioni Massimo Negrini

microRNA miR-221 is frequently over-expressed in a variety of human neoplasms. Aim of this study was to identify new miR-221 gene targets to improve our understanding on the molecular tumor-promoting mechanisms affected by miR-221. Gene expression profiling of miR-221-transfected-SNU-398 cells was analyzed by the Sylamer algorithm to verify the enrichment of miR-221 targets among down-modulated...

1999
Srinivasa M. Srinivasula Manzoor Ahmad Yin Guo Yi Zhan Yuri Lazebnik Teresa Fernandes-Alnemri Emad S. Alnemri

Alternatively spliced isoforms of certain apoptosis regulators, such as Bcl-x, Ced-4, and Ich-1, have been shown to play opposing roles in regulating apoptosis. Here, we describe the identification of an endogenous alternatively spliced isoform of caspase-9, named caspase-9b, which lacks the central large subunit caspase domain. Caspase-9b is detectable in many cell lines by PCR and at the mRNA...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Chun-Qi Li Laura J Trudel Gerald N Wogan

Nitric oxide (NO(*)) is mutagenic and, under appropriate conditions of exposure, also induces apoptosis in many in vitro and in vivo experimental models. Biochemical and cellular mechanisms through which NO(*) induces apoptosis are incompletely understood, but involve p53/mitochondria-dependent signaling pathways. In this study, we exposed human lymphoblastoid cells harboring either wild-type (...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2014
Joanna Tucka Haixiang Yu Kelly Gray Nichola Figg Janet Maguire Brian Lam Martin Bennett Trevor Littlewood

OBJECTIVE Vascular smooth muscle cell (VSMC) apoptosis occurs at low levels in atherosclerotic plaques and in vessel remodeling; however, the consequences and mediators of these levels are not known. Akt1 protects against VSMC apoptosis largely through inactivating target proteins such as forkhead class O transcription factor 3a (FoxO3a), but Akt1 signaling is reduced and FoxO3a activity is inc...

Journal: :Applied sciences 2022

Kaempferol, a flavonoid, contains plethora of therapeutic properties and has demonstrated its efficacy against cancer. This study aims to unravel the molecular targets that are being modulated by kaempferol on HeLa cells. Various assays were performed, namely: MTT assay, flow cytometry analyze DNA content quantitate apoptosis. Quantitative PCR protein profiling performed evaluate manifestation ...

2017
Bhaskar Saha Birija Sankar Patro Mrunesh Koli Ganesh Pai Jharna Ray Sandip K. Bandyopadhyay Subrata Chattopadhyay

In view of the inadequacy of neuroblastoma treatment, five hydroxystilbenes and resveratrol (Resv) were screened for their cytotoxic property against human neuroblastoma cell lines. The mechanism of cytotoxic action of the most potent compound, trans-4,4'-dihydroxystilbene (DHS) was investigated in vitro using human neuroblastoma cell lines. DHS was also tested in a mouse xenograft model of hum...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
David Lau Hilmar Bading

Cellular stress caused by genetic or environmental factors are considered to be the major inducers of cell death under pathological conditions. Induction of the apoptotic function of the tumor suppressor p53 is a common cellular response to severe genotoxic and oxidative stresses. In the nervous system, accumulation of p53 and increased p53 activity are associated with neuronal loss in acute an...

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