GABAergic hypothesis of anxiety was introduced many years ago, however, a limited number of supporting data were accumulated so far and the role of GABA(B) receptors in behavioral processes related to the anxiety disorders has not been resolved. In the present study, we examined anxiolytic activity of CGP 36742, a potent and selective GABA(B) receptor antagonist, in rodent tests/models. We have...

BACKGROUND The purpose of this study was to determine how the activation of different regulatory domains of the NMDA complex affects the antianxiety effect of antagonists acting at its distinct binding sites. METHODS The anxiolytic-like activity was assessed by the elevated plus-maze test in mice. RESULTS The anxiolytic activity of CGP 37849 (a competitive NMDA receptor antagonist) and L-70...

Background: The most widely prescribed medications for anxiety disorders are the Benzodiazepines; however, they have prominent side effects. Thus, interest in alternative medicine that affects the mind is growing. In Morocco folk medicine, the use of Mercurialis annua is commonly recommended for relief of anxiety, although no scientific information supporting this use is available and therefore...

Due to sedation, anticonvulsant and anti-pain effects, Leonuruscardiaca hashad a special place in traditional medicine of Iran and any of countries. The chemical composition of this plant contain alkaloids (stachydrine, Leonurine), Iridoid glycosides, labdanediterpene and terpene lactones like (Leo carlin and macrobid side), flavonoids, phenolic acids and tannins that these substances may affec...

introduction: sildenafil, a phosphodiesterase-5 (pde5) inhibitor, may have various effects on the central nervous system via the nitric oxide (no)-cyclic guanosine monophosphate (cgmp) pathway. preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. this study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...

putative activity of hydroalcoholic and aqueous infusion extracts of echium amoenum l. was investigated in mice using the rotarod model of motor coordination and the elevated plus maze model of anxiety. the extracts were administered intraperitonealy (i.p.) once, one hour before performing the tests. preliminary phytochemical study of the plant, with standard procedures, showed that it contains...

OBJECTIVE It has been shown that neurosteroids can either block or stimulate the development of chronic and rapid tolerance to the incoordination and hypothermia caused by ethanol consumption. The aim of the present study was to investigate the influence of isopregnanolone on the development of rapid tolerance to the anxiolytic effect of ethanol in mice. METHOD Male Swiss mice were pretreated...

introduction: dracocephalum polychaetum bornum is exclusively found in a limited geographical area in the kerman province it is used by the local people for treatment of abdominal pain, meteorism and musculoskeletal pain. no study has been performed on the effects of d. polychaetum bornum, so the aim of this work was to assess the role of the extract and essential oil of this plant on pain and ...

It is now well established that prior test experience can alter behavioural baselines and attenuate/abolish the anxiolytic efficacy of benzodiazepines in the elevated plus-maze paradigm. In view of evidence that different models of anxiety measure qualitatively distinct forms of anxiety-like behaviour, it is important to establish whether the effects of prior experience extend to other widely-u...