Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE. Objective: To investigate humoral immunity and specific-antibody formation in response to a...

A 73-year-old woman who had 25-year history of type 2 diabetes and 1-year history of chronic thyroiditis (Hashimoto’s disease) consulted Kawasaki Medical School, Okayama, Japan, for loss of appetite and weight loss (4.0 kg/1 month). Three days earlier, she had fever and left neck pain, and she started taking antibiotics. To examine her clinical condition, she was hospitalized in our institution...

Familial Mediterranean Fever (FMF) is an auto inflammatory disease[1] and also it can occur together with autoimmune disorders, such as Behçet's syndrome and systemic Lupus erythematosus[2,3]. Here, we present Familial Mediterranean fever and Hashimoto’s thyroiditis association in a 10-year-old girl. This girl was admitted to our hospital with a history of intermittent abdominal pain, fever, he...

the b-cell cd20 antigen is one of the most reliable surface targets in immunotherapy of b lymphoma. in this project, we studied the production and characterization of a new monoclonal antibody against chimeric human cd20 extra loops (hcd20 exl). the results showed that clone c12h, igg2/k isotype reacted with the antigen in elisa and immunoblot. the kd value was  found to be 2×10-9m and flow cyt...

cystic hydatid disease (hydatidosis) is one of the most important zoonosis that is caused by the larval stage of echinococcus granulosus . as its diagnosis by clinical symptoms alone is difficult and confusing, serologic diagnostic techniques are used to confirm the disease. these techniques can also be used for   epidemiologic studies. the present study was performed with a commercial human en...

in this study, the immunogenicity of three types of antigens (hydatid fluid, protoscolices and whole body of e. granulosus) was investigated in lambs by elisa. sixteen 4–6-month-old lambs of mixed sexes were divided into 4 groups of 4 lambs (three immunized and one control group). twelve lambs as immunized groups received 2 mg of hydatid fluid, protoscolices and whole body of e. granulosus ant...

celiac disease (cd) has been reported in association with genetic disorders ‎such as down’s syndrome and turner’s syndrome (ts). this study was undertaken to assess the prevalence of cd among a group of patients with ts. forty eight girls with ts and a control group composed of 48 healthy girls were screened for cd by iga antiendomysial antibody (iga-ema). total iga of serum was measured in all...

rubella a benign viral and modestly contagious illness in children, becomes a very dangerous story when acquired by pregnant women. the potential of its teratogenicity is obvious. since prevention is preferred to treatment, diagnosis of rubella infection syndrome being difficult in early stages of pregnancy, the uncertainly about fetuses being really infected and therapeutic abortion because of...