B-type natriuretic peptide (BNP)-natriuretic peptide receptor A (NPRA) and gastrin-releasing peptide (GRP)-GRP receptor (GRPR) systems contribute to spinal processing of itch. However, pharmacological and anatomic evidence of these two spinal ligand-receptor systems are still not clear. The aim of this study was to determine the spinal functions of BNP-NPRA and GRP-GRPR systems for regulating s...

Abstract Background and Aims Chronic kidney disease (CKD) its related symptoms significantly impact patients’ health-related quality of life (HRQoL). CKD-associated pruritus (CDK-aP) often affects patients with advanced CKD, particularly those on renal replacement therapy, remains mostly underrecognized by both medical providers. To explore the current impairment HRQoL due to CKD-aP, we conduct...

The prevalence of allergic skin disorders has increased rapidly, and development of therapeutic agents to alleviate the symptoms are still needed. In this study, we orally or topically administered the Janus kinase (JAK) inhibitors, tofacitinib and oclacitinib, in a mouse model of dermatitis, and compared the efficacy to reduce the itch and inflammatory response. In vitro effects of JAK inhibit...

Salvinorin A, TRK-820 (17-cyclopropylmethyl-3,14 -dihydroxy-4,5 epoxy-6 -[N-methyl-trans-3-(3-furyl) acrylamido]morphinan hydrochloride), and 3FLB (diethyl 2,4-di-[3-fluorophenyl]-3,7-dimethyl-3,7diazabicyclo[3.3.1]nonane-9-one-1,5-dicarboxylate) are structurally distinctly different from U50,488H [(trans)-3,4-dichloro-N-methyl-N[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide methanesulfonate],...

Abstract Introduction Vulvar lichen sclerosus (VLS) often presents with intense pruritus and recurrent painful lesions, negatively impacting quality of life and, potentially, the ability to engage in sexual penetration. VLS treatment ranges from topical steroids systemic antipruritic agents. No studies have yet characterized how concurrent dysfunction impacts treatment. Objective The objective ...

Abstract Background and Aims Chronic Kidney Disease associated pruritus (CKD-aP) is common affecting 40% of people with kidney disease receiving dialysis. It decreased health-related quality life (HRQoL) as assessed using disease-specific instruments. A better understanding how the severity CKD-aP related to distribution affected body parts generic HRQoL EQ-5D instrument could improve identific...

Abstract Background and Aims Chronic kidney disease-associated pruritus (CKD-aP) is a common condition in dialysis patients. It associated with impaired health-related quality of life (HRQoL) sleep disturbances. The pathophysiology remains unclear resulting limited treatment options lack guidelines. exact course CKD-aP after initiation has not been identified nor the state current medical treat...

BACKGROUND AND OBJECTIVES Total knee arthroplasty often results in marked postoperative pain. A recent meta-analysis supports the use of femoral nerve block or alternatively spinal injection of morphine plus local anaesthetic for post-operative analgesia. On the other hand, the use of intrathecal morphine may be associated with a large number of distressing side effects (itching, urinary retent...

The most commonly used topical pharmacologic agents for symptomatic management of hemorrhoids include vasoconstrictors, astringents, anesthetics, keratolytics, corticosteroids, and antipruritic agents. Some of these drugs have been involved in contact dermatitis [1-7]. A 57-year-old woman presented with a pruritic, sharply demarcated, erythematous rash on the anogenital area that spread within ...

Ubiquitination of the human opioid receptor (hKOR) expressed in Chinese hamster ovary (CHO) cells was observed in the presence of the proteasomal inhibitor N-benzoyloxycarbonyl (Z)-Leu-Leu-leucinal (MG132) and enhanced by the agonists ( )(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny) cyclohexyl] benzeneacetamide (U50,488H) and dynorphin A (Dyn A). The dominant-negative (DN) mutants GRK2-K22...