نتایج جستجو برای: antiproliferation
تعداد نتایج: 403 فیلتر نتایج به سال:
The orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) is a potent regulator of cholesterol metabolism and bile acid homeostasis. Recently, LRH-1 has been shown to play an important role in intestinal inflammation and in the progression of estrogen receptor positive and negative breast cancers and pancreatic cancer. Structural studies have revealed that LRH-1 can bind phospholipids...
The copper(I) complexes of N,N-diimine, N,O- and/or N, S-bidentate systems perform significant dose-dependent anticancer activity toward various cell lines viz. MCF-7, LNCap, PSN-1, A431, BxPC3, H157, A2780, HeLa, MDA-MB231, MGC-803 etc. can cross the cellular plasmalemma that results in accumulation copper ion cancer cells, exhibit effect and overcome multidrug resistance because these slightl...
Background: Cancer is one of the most prominent causes death worldwide. Ocimum gratissimum Linn. (Lamiaceae) leaves are used in many countries as a spice or medicine. Objectives: This study investigated essential oil O. and its major constituent, thymol, for cytotoxic activity against breast (AU565) cervical (HeLa) cancer cell lines. Methods: Preliminary screening was carried out using bench-to...
objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...
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