AIMS We have shown previously that non-toxic inhibition of the ubiquitin-proteasome system upregulates antioxidative defence mechanisms and protects endothelial cells from oxidative stress. Here, we have addressed the question whether the induction of antioxidative enzymes contributes to cardioprotection by non-toxic proteasome inhibition. METHODS AND RESULTS Treatment with 0.5 micromol/L MG1...

background and objective: free radicals cause many diseases in human and their neutralizing by antioxidants reduces risk of cancers. salvia officinalis from lamiaceae family is one of the valuable plants in traditional medicine. the present study aimed to evaluate the antioxidative and cytotoxic properties of ethanolic extract of the aerial parts of this plant on human prostate and cervical can...

When terrestrial environments get contaminated with long-lived gamma emitting radionuclides, plants that grow in these contaminated areas are exposed to gamma radiation during consecutive generations. Therefore it is important to evaluate the gamma induced stress response in plants in and between generations. The objective of this research is to reveal differences at the level of the antioxidat...

Cadmium (Cd) is considered as phytotoxic in nature, its toxicity on the plant development decrease antioxidative enzymes activities under stress environment. Castor (Ricinus Communis L.) a metal tolerant and ability to survive highly polluted soils. exhibited high level of Cd soil buildup antioxidants i.e., super oxide dismutase (SOD), peroxidase (POD) malondialdehyde (MAD) top ground parts str...

OBJECTIVE C-reactive protein (CRP) has been suggested to participate in the development of atherosclerosis, in part, by promoting endothelial dysfunction and impairing endothelial progenitor cell (EPC) survival and differentiation. In the present study, we evaluated the effects of CRP on antioxidative enzymes, reactive oxygen species production, telomerase activity, and apoptosis in human circu...

From the flowers of meadowsweet and inflorescence of hawthorn the whole set of phenolic acids and flavonoids was analysed by TLC. Phenolic compounds were determined both as free ones and those liberated by hydrolysis. Moreover, ethyl ether and ethyl acetate extracts obtained from the analysed plants before and after alkaline and enzymatic hydrolyses were evaporated under reduced pressure and re...

The reaction mechanisms by which antioxidants can exert their activity are: hydrogen atom transfer (HAT), proton coupled electron transfer (PCET), sequential proton loss electron transfer (SPLET), single electron transfer proton transfer (SET-PT), radical adduct formation, and sequential proton loss hydrogen atom transfer. The antioxidative activity of different compounds (flavones, flavonols, ...

The green unicellular alga, Haematococcus pluvialis has two antioxidative mechanisms against environmental oxidative stress: antioxidative enzymes in vegetative cells and the antioxidative ketocarotenoid, astaxanthin, in cyst cells. We added a reagent that generates superoxide anion radicals (O2 ), methyl viologen, to mature and immature cysts of H. pluvialis. Tolerance to methyl viologen was h...

Comparison of the concentrations and activities of components in the oxidative-antioxidative system between blood plasma and serum. Blood plasma and serum samples were obtained from 38 healthy adults to evaluate malondialdehyde concentration, the total antioxidative capacity, superoxide dismutase activity, protein and non-protein sulphydryl groups, ascorbate, haemoglobin, methaemoglobin and pro...

The antioxidant activities of Ulva faciata, Nizimuddinia zanardinii and Gracilaria corticata were investigated in Chabahar, Iran. Methanol extract and n-hexane, dichloromethane and ethylacetate fractions used for antioxidative properties test by the total antioxidative activity, 2,2-diphenyl-1-picryl-hydrazylhydrate (DPPH)  free radical scavenging activity, reduction power, metal chelating acti...