s | 31 1 Eskisehir Osmangazi University Medical School, Department of Pharmacology 2 Eskisehir Osmangazi University Medical School, Department of Anaesthesiology and Reanimation Abstract Objective: Curcumin, an active substance of the plant Curcuma longa, was reported to exhibit antiinflammatory, antioxidant, anticancer, antimicrobial ve antilipidemic features. The aim of this study is to inves...

Adenosine kinase (AK; EC 2.7.1.20) is a key intracellular enzyme regulating intra-and extracellular concentrations of adenosine (ADO), an endogenous neuromodulator, antinociceptive, and anti-inflammatory autocoid. AK inhibition provides a means of potentiating local tissue concentrations of endogenous ADO, and AK inhibitors may have therapeutic potential as analgesic and anti-inflammatory agent...

To analyze the selectivity of delta receptor subtypes to regulate different classes of G proteins, the expression of the alpha-subunits of Gi2, Gi3, Go1, Go2, Gq and G11 transducer proteins was reduced by administration of oligodeoxynucleotides (ODNs) complementary to sequences in their respective mRNAs. Mice receiving antisense ODNs to Gi2 alpha, Gi3 alpha, Go2 alpha and G11 alpha subunits sho...

OBJECTIVE The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum. MATERIALS AND METHODS Antinociceptive activities of ...

INTRODUCTION Grangea maderaspatana (L.) Poir. (Asteraceae), a popular Indian medicinal plant is traditionally used for rheumatism in the knee joint and pain in the muscles. AIM To investigate antinociceptive and antirheumatic activity of G. maderaspatana (L.) Poir. using experimental models. MATERIALS AND METHODS Antinociceptive activity of methanolic extract of G. maderaspatana (L.) Poir. ...

serotonin specific reuptake inhibitors (ssri) may induce antinociception however, the mechanism of this effect is not clear. ssrls increase 5-ht levels in neuronal synapses and facilitate serotonergic activity. in this study, therefore, the activity of para-chlorophenylalanine (pcpa), which reduces 5-ht release, and 5- hydroxy tryptophan (5-htp), a precursor of 5-ht, were examined on the antino...

We have previously reported the chemistry and antinociceptive properties of a series of glycosylated enkephalin analogs (glycopeptides) exhibiting approximately equal affinity and efficacy at δ opioid receptors (DORs) and μ opioid receptors (MORs). More detailed pharmacology of the lead glycopeptide MMP-2200 [H₂N-Tyr-D-Thr-Gly-Phe-Leu-Ser-(O-β-D-lactose)-CONH₂] is presented. MMP-2200 produced d...

Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO). The major component present in the essential oil was beta-phellandrene (29.39%). Its antinociceptive activity was tested through animal models (formalin-, capsaicin-, and glutamate-induced paw lic...

OBJECTIVE(S) The aim of study was to investigate the antinociceptive effect of intracerebroventricular (ICV) microinjection of Origanum vulgare (ORG) extract and possible involvement of opioid receptors. MATERIALS AND METHODS Cannula was inserted into left ventricle of male rats. Five days after surgery Tail Flick Latency (TFL) was measured after ICV microinjection of, ORG (1, 3 and 6 µg / ra...

The acute treatment of mice with an ethanolic extract from the seed pod of Dioclea grandiflora (EDgP) at doses of 75, 150 and 300 mg/kg by intraperitoneal administration produced a significant antinociceptive effect as displayed by the acetic acid-induced writhing test and the formalin test. The antinociception was observed through the first (neurogenic pain) and second (inflammatory pain) phas...